Applying modern Omic technologies to the Neuronal Ceroid Lipofuscinoses

Biochim Biophys Acta Mol Basis Dis. 2020 Sep 1;1866(9):165498. doi: 10.1016/j.bbadis.2019.06.012. Epub 2019 Jun 15.

Abstract

The Neuronal Ceroid Lipofuscinoses are a group of severe and progressive neurodegenerative disorders, which generally present during childhood. With new treatments emerging on the horizon, there is a growing need to understand the specific disease mechanisms as well as identify prospective biomarkers for use to stratify patients and monitor treatment. The use of Omics technologies to NCLs has the potential to address this need. We discuss the recent use and outcomes of Omics to various forms of NCL including identification of interactomes, affected biological pathways and potential biomarker candidates. We also identify common pathways affected in NCL across the reviewed studies.

Keywords: Batten disease; CLN1–14; Metabolomics; Neuronal Ceroid Lipofuscinoses; Proteomics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomarkers
  • Genomics*
  • Humans
  • Neuronal Ceroid-Lipofuscinoses* / genetics
  • Neuronal Ceroid-Lipofuscinoses* / metabolism
  • Proteomics*

Substances

  • Biomarkers