Abstract
Coronaviruses are a class of RNA viruses that can cause respiratory and intestinal infections in animals and humans. SARS-CoV, MERS-CoV, and a novel coronavirus (SARS-CoV-2 [2019-nCoV]) belong to the family Coronaviridae and the genus Betacoronavirus. At present, the understanding of SARS-CoV-2 is getting deeper and deeper. In order to better prevent and treat SARS-CoV-2, this article compares the infectivity, pathogenicity, and related clinical characteristics of the three human pathogenic coronaviruses, SARS-CoV-2, SARS-CoV, and MERS-CoV to help us further understand the pathogenic characteristics of novel coronaviruses.
Keywords:
MERS-CoV; SARS-CoV; SARS-CoV-2; clinical features; pneumonia.
© 2020 APMIS. Published by John Wiley & Sons Ltd.
MeSH terms
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Angiotensin-Converting Enzyme 2
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Antiviral Agents / therapeutic use
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Betacoronavirus / genetics
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Betacoronavirus / metabolism
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Betacoronavirus / pathogenicity*
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COVID-19
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COVID-19 Serotherapy
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COVID-19 Testing
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Clinical Laboratory Techniques / methods
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Coronavirus Infections / diagnosis
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Coronavirus Infections / epidemiology*
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Coronavirus Infections / mortality
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Coronavirus Infections / therapy
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Humans
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Immunization, Passive / methods
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Infectious Disease Incubation Period
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Middle East Respiratory Syndrome Coronavirus / genetics
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Middle East Respiratory Syndrome Coronavirus / metabolism
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Middle East Respiratory Syndrome Coronavirus / pathogenicity*
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Pandemics*
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Peptidyl-Dipeptidase A / genetics
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Peptidyl-Dipeptidase A / metabolism
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Pneumonia, Viral / diagnosis
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Pneumonia, Viral / epidemiology*
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Pneumonia, Viral / mortality
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Pneumonia, Viral / therapy
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Protein Binding
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SARS-CoV-2
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Severe Acute Respiratory Syndrome / diagnosis
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Severe Acute Respiratory Syndrome / epidemiology*
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Severe Acute Respiratory Syndrome / mortality
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Severe Acute Respiratory Syndrome / therapy
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Severe acute respiratory syndrome-related coronavirus / genetics
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Severe acute respiratory syndrome-related coronavirus / metabolism
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Severe acute respiratory syndrome-related coronavirus / pathogenicity*
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Severity of Illness Index
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Spike Glycoprotein, Coronavirus / genetics
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Spike Glycoprotein, Coronavirus / metabolism
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Survival Analysis
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Tomography, X-Ray Computed
Substances
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Antiviral Agents
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Spike Glycoprotein, Coronavirus
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Peptidyl-Dipeptidase A
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ACE2 protein, human
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Angiotensin-Converting Enzyme 2