Asymmetry and anomalies of the circle of Willis in fetal brain. Microsurgical study and functional remarks

Surg Neurol. 1985 Nov;24(5):563-70. doi: 10.1016/0090-3019(85)90275-7.

Abstract

The arteries of the circle of Willis in fetal brains of 20-40 weeks of gestational age were studied with the operating microscope. The majority of fetuses were between 24-32 weeks of age. Our findings were as follows: 1) the average diameters of all segments were 4-5 times narrower than the average diameters in adults, and the average lengths of the same segments were 2-2.5 times shorter than the same lengths in adults; 2) the number of perforators corresponded with the perforating arteries in adults; 3) hypoplastic segments, as well as anomalies and variations, were identified; 4) calibers almost equal in size between the right and left corresponding segments were found in a high proportion of cases; 5) in the majority of cases a polygon, much like the "precarious" circle in adults, was dissected. The "fetal" or the "ideal" circles were found in a low proportion of cases.

MeSH terms

  • Adult
  • Circle of Willis / abnormalities*
  • Circle of Willis / anatomy & histology
  • Female
  • Fetal Diseases / complications
  • Fetal Diseases / pathology*
  • Humans
  • Intracranial Aneurysm / complications
  • Intracranial Aneurysm / pathology
  • Microsurgery
  • Pregnancy