Neurotoxicity of novel water-soluble contrast media for intrathecal application

Invest Radiol. 1980 Nov-Dec;15(6 Suppl):S254-9. doi: 10.1097/00004424-198011001-00054.

Abstract

Novel nonionic contrast media were tested by injection into the subarachnoid space of the anterior fossae of guinea pigs, followed by EEG recording and histologic examination. Iopamidol was found to be more epileptogenic than metrizamide and P-297.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Central Nervous System / diagnostic imaging
  • Central Nervous System / drug effects*
  • Central Nervous System / physiology
  • Contrast Media / administration & dosage
  • Contrast Media / toxicity*
  • Electroencephalography
  • Guinea Pigs
  • Injections, Spinal
  • Neuroradiography / methods
  • Seizures / chemically induced*
  • Solubility

Substances

  • Contrast Media