Are infantile myofibromatosis, congenital fibrosarcoma and congenital haemangiopericytoma histogenetically related?

Histopathology. 1995 Jan;26(1):57-62. doi: 10.1111/j.1365-2559.1995.tb00621.x.

Abstract

Infantile myofibromatosis, congenital fibrosarcoma and congenital/infantile haemangiopericytoma are generally considered distinct entities. Overlapping microscopic features between infantile myofibromatosis and congenital fibrosarcoma, and between infantile myofibromatosis and congenital/infantile haemangiopericytoma, however, have been noted, but not formally reported. This report concerns six neonatal tumours, each exhibiting more than one of the above patterns, supporting a histogenetic relationship among these entities. Immunohistochemistry for smooth muscle actin was found to be useful in the diagnosis of congenital/infantile haemangiopericytoma, and also served to support a histogenetic relationship with the other two entities under consideration.

MeSH terms

  • Actins / analysis
  • Female
  • Fibrosarcoma / chemistry
  • Fibrosarcoma / congenital
  • Fibrosarcoma / pathology*
  • Hemangiopericytoma / chemistry
  • Hemangiopericytoma / congenital
  • Hemangiopericytoma / pathology*
  • Humans
  • Immunohistochemistry
  • Infant
  • Infant, Newborn
  • Male
  • Myofibromatosis / congenital
  • Myofibromatosis / pathology*
  • Soft Tissue Neoplasms / chemistry
  • Soft Tissue Neoplasms / pathology*
  • Vimentin / analysis

Substances

  • Actins
  • Vimentin