Abstract
Therapy of brain tumors has been limited by lack of effective methods of drug delivery. Systemic administration often fails to achieve therapeutic concentrations of drugs within intracranial tumors despite toxic systemic levels. This article discusses new methods for delivering therapeutic agents to brain tumors, including intra-arterial, intrathecal, intraventricular, and interstitial administration techniques.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adult
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Agents / adverse effects
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Brain Neoplasms / drug therapy*
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Brain Neoplasms / mortality
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Brain Neoplasms / radiotherapy
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Brain Neoplasms / surgery
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Carmustine / administration & dosage
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Carmustine / adverse effects
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Chemotherapy, Adjuvant
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Combined Modality Therapy
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Drug Administration Routes
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Drug Implants
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Humans
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Survival Rate
Substances
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Antineoplastic Agents
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Drug Implants
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Carmustine