Abstract
A group of 26 patients with carcinoma of the head and neck region was treated by superselective intra-arterial infusion of cisplatin (CDDP)-carboplatin (CBDCA). The tumor locations included the tongue (n = 4), oral base (n = 2), nasopharynx (n = 2), oropharynx (n = 8), hypopharynx (n = 4) and larynx (n = 4). Using the coaxial technique, a microcatheter was placed in the lingual, ascending pharyngeal, facial and superior thyroidal arteries according to the location of the tumor. Under imaging studies, CDDP (50 mg/m2)-CBDCA (300 mg/m2) was infused into the vessel, via injectors at the rate of 12.5 ml/min. One to five injections were given every 4 weeks. During and following the chemotherapy the patients received radiotherapy (n = 22), surgery (n = 4) or both (n = 3). Sixty-six sessions of intra-arterial chemotherapy were given with no major complications. Drug-related systemic side effects were mild. The overall response rate was 96% (complete response (CR) 50% and partial response (PR) 46%). Superselective CDDP-CBDCA combined infusion is feasible, relatively non-toxic, and important as multimodality therapy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Agents / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Carboplatin / administration & dosage*
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Carboplatin / adverse effects
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Carcinoma, Squamous Cell / drug therapy*
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Carcinoma, Squamous Cell / surgery
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Catheterization, Peripheral / instrumentation
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Chemotherapy, Cancer, Regional Perfusion*
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Cisplatin / administration & dosage*
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Cisplatin / adverse effects
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Combined Modality Therapy
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Feasibility Studies
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Head and Neck Neoplasms / drug therapy*
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Head and Neck Neoplasms / surgery
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Humans
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Hypopharyngeal Neoplasms / drug therapy
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Hypopharyngeal Neoplasms / surgery
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Infusions, Intra-Arterial
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Laryngeal Neoplasms / drug therapy
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Laryngeal Neoplasms / surgery
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Middle Aged
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Mouth Neoplasms / drug therapy
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Mouth Neoplasms / surgery
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Nasopharyngeal Neoplasms / drug therapy
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Nasopharyngeal Neoplasms / surgery
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Oropharyngeal Neoplasms / drug therapy
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Oropharyngeal Neoplasms / surgery
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Radiotherapy, Adjuvant
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Remission Induction
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Tongue Neoplasms / drug therapy
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Tongue Neoplasms / surgery
Substances
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Antineoplastic Agents
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Carboplatin
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Cisplatin