Abstract
We report intrathecal use of gadolinium DTPA for MRI of the cerebrospinal fluid (CSF). In two patients with leptomeningeal carcinomatosis, we injected 0.01 mmol gadolinium DTPA into the lateral ventricle via an Ommaya device. Coronal T1-weighted images of the head were obtained at 0.2 T prior to and after injection. There was pronounced enhancement of CSF close to the injection site, allowing good delineation of CSF and surrounding brain tissue. No side effects occurred. MRI with intrathecal administration of highly diluted gadolinium DTPA may be a promising alternative to conventional investigation of CSF-filled cavities using iodinated X-ray contrast media or radionuclides.
MeSH terms
-
Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
-
Antineoplastic Combined Chemotherapy Protocols / adverse effects
-
Breast Neoplasms / diagnosis
-
Breast Neoplasms / drug therapy*
-
Cerebral Ventricles / pathology
-
Contrast Media / administration & dosage*
-
Equipment Failure Analysis
-
Female
-
Gadolinium DTPA
-
Humans
-
Image Processing, Computer-Assisted
-
Infusion Pumps, Implantable*
-
Injections, Intraventricular / instrumentation
-
Magnetic Resonance Imaging / instrumentation*
-
Meningeal Neoplasms / diagnosis
-
Meningeal Neoplasms / drug therapy
-
Meningeal Neoplasms / secondary*
-
Middle Aged
-
Organometallic Compounds*
-
Pentetic Acid / analogs & derivatives*
-
Stomach Neoplasms / diagnosis
-
Stomach Neoplasms / drug therapy*
-
Subarachnoid Space / pathology
Substances
-
Contrast Media
-
Organometallic Compounds
-
Pentetic Acid
-
Gadolinium DTPA