Cyclosporine-related reversible posterior leukoencephalopathy: MRI

Neuroradiology. 1997 Oct;39(10):711-5. doi: 10.1007/s002340050492.

Abstract

Three patients aged 48, 11 and 40 years, two of whom were recent recipients of renal transplants and one of a bone marrow transplant, developed seizures, with cortical blindness in two cases. All were immunosuppressed with cyclosporine and were hypertensive at the onset of symptoms. MRI showed predominantly posterior signal changes in all three cases. The abnormalities were more conspicuous on fast FLAIR images than on conventional T2-weighted spin-echo images.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Blindness, Cortical / chemically induced
  • Blindness, Cortical / diagnosis
  • Bone Marrow Transplantation / immunology
  • Child
  • Cyclosporine / administration & dosage
  • Cyclosporine / adverse effects*
  • Demyelinating Diseases / chemically induced*
  • Demyelinating Diseases / diagnosis
  • Female
  • Humans
  • Image Enhancement
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / adverse effects*
  • Kidney Transplantation / immunology
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Postoperative Complications / chemically induced
  • Postoperative Complications / diagnosis
  • Seizures / chemically induced
  • Seizures / diagnosis

Substances

  • Immunosuppressive Agents
  • Cyclosporine