Abstract
Treatment of experimental allergic encephalomyelitis (EAE) in two strains of monkeys with large amounts of myelin basic basic protein (BP) fails unless an adjunct is also used. In both strains the adjunct by itself is more effective than BP by itself, but in the one strain which could be investigated sufficiently, the combination can be made almost totally effective in reversing EAE. The adjunct varies with the strain of monkey, an antibiotic in Macaca mulatta and a steroid in Macaca fascicularis. Similar adjunctive treatments should be considered in the management of multiple sclerosis, for EAE remains one of the best studied models.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acids / administration & dosage
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Amino Acids / immunology
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Animals
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Cephalothin / administration & dosage
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Dexamethasone / administration & dosage
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Encephalomyelitis, Autoimmune, Experimental / therapy*
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Freund's Adjuvant / administration & dosage
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Haplorhini
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Macaca fascicularis
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Macaca mulatta
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Myelin Basic Protein / administration & dosage
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Myelin Basic Protein / immunology
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Myelin Basic Protein / therapeutic use*
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Polymers / administration & dosage
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Species Specificity
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Trypsin Inhibitors / administration & dosage
Substances
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Amino Acids
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Myelin Basic Protein
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Polymers
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Trypsin Inhibitors
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Dexamethasone
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Freund's Adjuvant
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Cephalothin