Abstract
SOX10, a new member of the SOX gene family, is a transcription factor defective in the Dom (Dominant megacolon) mouse and in the human Shah-Waardenburg syndrome. To help unravel its physiological role during human development, we studied SOX10 gene expression in embryonic, fetal, and adult human tissues by Northern blot and in situ hybridization. As in mice, the human SOX10 gene was essentially expressed in the neural crest derivatives that contribute to the formation of the peripheral nervous system, and in the adult central nervous system. Nevertheless, it was more widely expressed in humans than in rodents. The spatial and temporal pattern of SOX10 expression supports an important function in neural crest development.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Blotting, Northern
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Central Nervous System / chemistry
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Central Nervous System / embryology
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DNA-Binding Proteins / genetics*
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Embryo, Mammalian / chemistry*
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Embryonic and Fetal Development / genetics*
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Gene Expression / genetics
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High Mobility Group Proteins / genetics*
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Humans
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In Situ Hybridization
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Neural Crest / chemistry
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Neural Crest / cytology
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Neural Crest / embryology
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RNA, Messenger / analysis
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RNA, Messenger / genetics
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SOXE Transcription Factors
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Tissue Distribution
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Transcription Factors / genetics
Substances
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DNA-Binding Proteins
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High Mobility Group Proteins
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RNA, Messenger
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SOX10 protein, human
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SOXE Transcription Factors
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Sox10 protein, mouse
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Transcription Factors