Gonadotropin-releasing hormone deficiency in the human (idiopathic hypogonadotropic hypogonadism and Kallmann's syndrome): pathophysiological and genetic considerations

Endocr Rev. 1998 Oct;19(5):521-39. doi: 10.1210/edrv.19.5.0344.
No abstract available

Publication types

  • Review

MeSH terms

  • Animals
  • DAX-1 Orphan Nuclear Receptor
  • DNA-Binding Proteins / chemistry
  • Diagnosis, Differential
  • Extracellular Matrix Proteins*
  • Female
  • Genetic Linkage
  • Gonadotropin-Releasing Hormone / deficiency*
  • Gonadotropin-Releasing Hormone / genetics
  • Gonadotropin-Releasing Hormone / physiology
  • Gonadotropins / metabolism*
  • Humans
  • Hypogonadism / genetics*
  • Hypogonadism / physiopathology
  • Kallmann Syndrome / genetics*
  • Kallmann Syndrome / physiopathology
  • Luteinizing Hormone / metabolism
  • Male
  • Nerve Tissue Proteins / chemistry
  • Olfaction Disorders / genetics
  • Olfaction Disorders / physiopathology
  • Pedigree
  • Pregnancy
  • Receptors, Retinoic Acid / chemistry
  • Repressor Proteins*
  • Transcription Factors / chemistry
  • X Chromosome / genetics
  • X Chromosome / physiology

Substances

  • ANOS1 protein, human
  • DAX-1 Orphan Nuclear Receptor
  • DNA-Binding Proteins
  • Extracellular Matrix Proteins
  • Gonadotropins
  • NR0B1 protein, human
  • Nerve Tissue Proteins
  • Receptors, Retinoic Acid
  • Repressor Proteins
  • Transcription Factors
  • Gonadotropin-Releasing Hormone
  • Luteinizing Hormone