We report a case of an unusually prominent persistent notochordal canal involving the T12-L5 vertebrae. This rare anatomic variation was discovered as an incidental finding in a patient with lymphoma undergoing MR imaging for evaluation of back pain. MR images showed a vertically oriented canal contiguous with the intervertebral disks traversing the anterior aspect of each affected vertebral body. Plain films showed a sclerotic rimmed central channel that flared at each vertebral endplate to merge with the disk spaces.