Whipple disease confined to the central nervous system in childhood

AJNR Am J Neuroradiol. 1996 Sep;17(8):1589-91.

Abstract

In a case of pediatric Whipple disease confined to the central nervous system, white matter lesions initially appeared as areas of very low signal intensity on T1-weighted MR images and as areas of hyperintensity on proton density-weighted and T2-weighted images, and showed slight peripheral enhancement on delayed contrast-enhanced T1-weighted images. On MR studies obtained 3 and 6 months after antibiotic therapy, the lesions had decreased in size and no longer enhanced. They became progressively less hypointense on T1-weighted images and less hyperintense on T2-weighted images.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Anti-Infective Agents / therapeutic use
  • Brain Diseases / diagnosis*
  • Cerebellar Diseases / diagnosis
  • Child, Preschool
  • Chloramphenicol / therapeutic use
  • Contrast Media
  • Follow-Up Studies
  • Gliosis / pathology
  • Humans
  • Image Enhancement
  • Magnetic Resonance Imaging*
  • Male
  • Necrosis
  • Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use
  • Whipple Disease / diagnosis*

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Contrast Media
  • Chloramphenicol
  • Trimethoprim, Sulfamethoxazole Drug Combination