Andreas Vesalius is attributed the discovery of white matter in the 16th century but van
Leeuwenhoek is arguably the first to have observed myelinated fibers in 1717. A globular myelin …

Superwarfarins were developed following the emergence of warfarin resistance in rodents.
Compared to warfarin, superwarfarins have much longer half‐lives and stronger affinity to …

The importance and essential functions of glial cells in the nervous system are now
beginning to be understood and appreciated. Glial cell lines have been instrumental in the …

PURPOSE To study bystander demyelination in multiple sclerosis with an experimental in vivo
model of toxic demyelination. METHODS Toxic demyelinating lesions were created in two …

Background Under pathological conditions, microglia produce proinflammatory mediators
which contribute to neurologic damage, and whose levels can be modulated by endogenous …

Extracellular vesicles (EVs) are membrane nanovesicles of diverse sizes secreted by different
cell types and are involved in intercellular communication. EVs shuttle proteins, nucleic …

Myelin repair is inhibited in multiple sclerosis (MS), ultimately leading to axonal damage
and disability. We aimed to understand the transcriptional mechanisms of regeneration in …

Converging data suggest that nitric oxide (NO) production by cytokine-induced immune
cells in demyelinating lesions is involved in multiple sclerosis (MS). High levels of NO may …

: Nitric oxide (NO) produced in inflammatory lesions may play a major role in the destruction
of oligodendrocytes in multiple sclerosis and experimental allergic encephalomyelitis. The …

Various animal models with experimental allergic encephalomyelitis (EAE) have been developed
applying immunologic, virologic, toxic and traumatic parameters in order to understand …