Chronic inflammation and oxidative stress in human carcinogenesis
A Federico, F Morgillo, C Tuccillo… - … journal of cancer, 2007 - Wiley Online Library
A wide array of chronic inflammatory conditions predispose susceptible cells to neoplastic
transformation. In general, the longer the inflammation persists, the higher the risk of cancer. A …
transformation. In general, the longer the inflammation persists, the higher the risk of cancer. A …
[HTML][HTML] Role of oxidative stress in pathophysiology of nonalcoholic fatty liver disease
…, A Aglitti, C Loguercio, A Federico… - … medicine and cellular …, 2018 - hindawi.com
Liver steatosis without alcohol consumption, namely, nonalcoholic fatty liver disease (NAFLD),
is a common hepatic condition that encompasses a wide spectrum of presentations, …
is a common hepatic condition that encompasses a wide spectrum of presentations, …
Mitochondria, oxidative stress and neurodegeneration
A Federico, E Cardaioli, P Da Pozzo, P Formichi… - Journal of the …, 2012 - Elsevier
Mitochondria are involved in ATP supply to cells through oxidative phosphorylation (OXPHOS),
synthesis of key molecules and response to oxidative stress, as well as in apoptosis. …
synthesis of key molecules and response to oxidative stress, as well as in apoptosis. …
[PDF][PDF] TREM2 acts downstream of CD33 in modulating microglial pathology in Alzheimer's disease
A Griciuc, S Patel, AN Federico, SH Choi, BJ Innes… - Neuron, 2019 - cell.com
The microglial receptors CD33 and TREM2 have been associated with risk for Alzheimer's
disease (AD). Here, we investigated crosstalk between CD33 and TREM2. We showed that …
disease (AD). Here, we investigated crosstalk between CD33 and TREM2. We showed that …
FERONIA controls pectin-and nitric oxide-mediated male–female interaction
…, FLJ Yeh, R Yvon, H Carpenter, AN Federico… - Nature, 2020 - nature.com
Species that propagate by sexual reproduction actively guard against the fertilization of an
egg by multiple sperm (polyspermy). Flowering plants rely on pollen tubes to transport their …
egg by multiple sperm (polyspermy). Flowering plants rely on pollen tubes to transport their …
Accurate, robust, and automated longitudinal and cross-sectional brain change analysis
Quantitative measurement of brain size, shape, and temporal change (for example, in order
to estimate atrophy) is increasingly important in biomedical image analysis applications. …
to estimate atrophy) is increasingly important in biomedical image analysis applications. …
Evidence of early cortical atrophy in MS: relevance to white matter changes and disability
…, L Guidi, A Ghezzi, E Montanari, A Cifelli, A Federico… - Neurology, 2003 - AAN Enterprises
Objective: To assess cortical gray matter (GM) changes in MS and establish their relevance
to clinical disability and to inflammatory changes of white matter (WM) in patients with the …
to clinical disability and to inflammatory changes of white matter (WM) in patients with the …
Gene therapy for Alzheimer's disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation
A Griciuc, AN Federico, J Natasan… - Human molecular …, 2020 - academic.oup.com
Neuroinflammation is a key contributor to the pathology of Alzheimer’s disease (AD). CD33 (Siglec-3)
is a transmembrane sialic acid-binding receptor on the surface of microglial cells. …
is a transmembrane sialic acid-binding receptor on the surface of microglial cells. …
Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trial
…, M Angelico, I Cacciola, G Elia, A Federico… - The Lancet, 2018 - thelancet.com
Background Evidence is scarce on the efficacy of long-term human albumin (HA) administration
in patients with decompensated cirrhosis. The human Albumin for the treatmeNt of …
in patients with decompensated cirrhosis. The human Albumin for the treatmeNt of …
Oxidative stress in viral and alcoholic hepatitis
C Loguercio, A Federico - Free radical Biology and medicine, 2003 - Elsevier
Liver damage ranges from acute hepatitis to hepatocellular carcinoma, through apoptosis,
necrosis, inflammation, immune response, fibrosis, ischemia, altered gene expression and …
necrosis, inflammation, immune response, fibrosis, ischemia, altered gene expression and …