… HD patients with particularly violent chorea have movements indistinguishable from classic
vascular ballism (Albin, RL, Young, AB and Penney, JB, unpublished observations). Similarly…

Traumatic brain injury (TBI) remains a major public health problem globally. In the United
States the incidence of closed head injuries admitted to hospitals is conservatively estimated to …

… It is clear that such a list can never be complete as modern mass spectrometry is still a
young discipline enjoying rapid and dynamic growth, and new chemicals and materials are …

… Although a number of younger at-risk individuals were also analysed as part of this study, for
… E 4 Ab was digested to completion with 20 - 4 : kb. - 4 9 kb. units of HindIII in a volume of 30 …

The Unified Huntington's Disease Rating Scale (UHDRS) was developed as a clinical rating
scale to assess four domains of clinical performance and capacity in HD: motor function, …

The sirtuins are members of the histone deacetylase family of proteins that participate in a
variety of cellular functions and play a role in aging. We identified a potent inhibitor of sirtuin 2 (…

… In a recent theoretical treatment of basal ganglia motor function, Penney and Young (36) …
On this basis, Penney and Young (36) hypothesized that the striato-GPe-STN circuit might …

Huntington's disease is an autosomal-dominant progressive neurodegenerative disorder
resulting in specific neuronal loss and dysfunction in the striatum and cortex 1 . The disease is …

Huntington's disease (HD) pathology is well understood at a histological level but a comprehensive
molecular analysis of the effect of the disease in the human brain has not previously …

Parkinson’s disease affects 5 million people worldwide, but the molecular mechanisms
underlying its pathogenesis are still unclear. Here, we report a genome-wide meta-analysis of …