Considerable progress has been made in unraveling the genetic etiology of amyotrophic
lateral sclerosis (ALS), the most common form of adult-onset motor neuron disease and the …

Two decades after the discovery that 20% of familial amyotrophic lateral sclerosis (ALS)
cases were linked to mutations in the superoxide dismutase-1 (SOD1) gene, a substantial …

Background The disease course of amyotrophic lateral sclerosis (ALS) is rapid and, because
its pathophysiology is unclear, few effective treatments are available. Genetic research …

Background The intrathecally administered antisense oligonucleotide tofersen reduces
synthesis of the superoxide dismutase 1 (SOD1) protein and is being studied in patients with …

Background Geographical differences in the incidence of amyotrophic lateral sclerosis (ALS)
have been reported in the literature but comparisons across previous studies are limited by …

MATR3 is an RNA- and DNA-binding protein that interacts with TDP-43, a disease protein
linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Using exome …

The cause of amyotrophic lateral sclerosis (ALS) is still unknown. A possible relationship
between ALS and sport participation has been supposed, but never definitely demonstrated. …

Although amyotrophic lateral sclerosis (ALS) is relatively rare, the socioeconomic significance
of the disease is extensive. It is therefore vital to project the epidemiologic trend of ALS. To …

Amyotrophic lateral sclerosis is a fatal neurodegenerative disease. The discovery of genes
associated with amyotrophic lateral sclerosis, commencing with SOD1 in 1993, started fairly …

Objective: There is increasing evidence that common genetic risk factors underlie
frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Recently, …