Primary empty sella (PES) is characterized by the herniation of the subarachnoid space within
the sella, which is often associated with variable degrees of flattening of the pituitary gland …

Ki-67 Labeling Index is an immunocytochemical marker of cell proliferation. The correlation
of Ki-67 expression with pituitary adenomas recurrence has been investigated and is highly …

Hypophysitis is a rare and potentially life-threatening disease, characterized by an elevated
risk of complications, such as occurrence of acute central hypoadrenalism, persistent …

Aim To gather data regarding factors predicting responsiveness to pasireotide in acromegaly.
Patients and methods SSTR2a, SSTR3, SSTR5, AIP, Ki-67 and the adenoma subtype …

Context: Cross-sectional studies showed an elevated prevalence of vertebral fractures in
acromegaly. However, no data are available on incident vertebral fractures in this clinical …

At the end of January 2020, the World Health Organization (WHO) declared the SARS-Cov-2
(or Coronavirus 19 [COVID-19]) infection a global health emergency [1]. The virus, …

Obesity is characterized by increased leptin levels and insulin resistance, whereas blunted
GH secretion is paired with normal, low, or high plasma IGF-I levels. To investigate body …

Introduction Nonalcoholic fatty liver disease (NAFLD) has been described in adult GH
deficiency syndrome. Furthermore, chronic liver disease can be associated with significant …

Background and Objective: In 2004, the World Health Organization defined atypical pituitary
adenomas as those with a Ki-67 expression> 3%, an excessive p53 expression and …

OBJECTIVE: To highlight the clinical role of standard GH replacement treatment on fertility
and pregnancy outcomes in four infertile eugonadal women with GH deficiency (GHD). …