Genomic triplication of the α-synuclein gene (SNCA) has been reported to cause hereditary
early-onset parkinsonism with dementia. These findings prompted us to screen for …

Background Severe forms of dystonia respond poorly to medical treatment. Deep-brain
stimulation is a reversible neurosurgical procedure that has been used for the treatment of …

Aims: The pathophysiological role of iron in Parkinson's disease (PD) was assessed by a
chelation strategy aimed at reducing oxidative damage associated with regional iron …

Background: Apathy is usually defined as reduced interest and participation in various activities.
It is a frequent consequence of neurological and psychiatric disorders. Although various …

Background Previous studies have suggested that patients with Lewy-body-related dementias
might benefit from treatment with the N-methyl D-aspartate receptor antagonist memantine…

Autosomal-recessive early-onset parkinsonism is clinically and genetically heterogeneous.
The genetic causes of approximately 50% of autosomal-recessive early-onset forms of …

Background We have previously reported the efficacy and safety of bilateral pallidal stimulation
for primary generalised dystonia in a prospective, controlled, multicentre study with 1 …

Background: Severe gait disturbances and freezing episodes (frequently resistant to optimal
dopaminergic treatment) often appear in advanced Parkinson disease (PD). Even several …

Genome-wide analysis of a multi-incident family with autosomal-dominant parkinsonism has
implicated a locus on chromosomal region 3q26-q28. Linkage and disease segregation is …

The objective of this study was to use the Lille Apathy Rating Scale to assess apathy in a
large population of Parkinson's disease (PD) patients and identify several different apathy …