… (B to D) In vivo MPO inhibition as measured by bis-5-hydroxytryptamide-diethylenetriaminepentaacetate-gadolinium
imaging. (B) Representative T 1 -weighted midventricular slices …

… (B) Schematic of Y-maze task and spontaneous alternation behavior (male, F (3,31) =
3.935, P < 0.05; female, F (2,19) = 7.416, P < 0.01). Total arm entries were comparable among …

… (B) Quantification of imaging reveals significant difference in MPO activity in vivo (P = 0.03,
n = 8 per group). (C) In vitro assays on whole tissue homogenates using ADHP or TMB do not …

… Left middle cerebral artery (MCA) M2 occlusion visualized on (A) axial and (B) coronal
maximum intensity projection images in a 72-year-old female with admission NIH Stroke Scale of …

… be cleaved by cathepsin, B, L, and S… B (Cath B 680 FAST) was successfully used in mice
with EAE, where it distinguished EAE from control mice and demonstrated elevated cathepsin B …

… (b) Relative fold increase of different myeloid cell populations in NASH over sham (n=5
per group). (c) Immunohistochemistry for MPO in NASH compared with sham mice (arrows …

… , macrophages, and microglia in the central nervous system can secrete a variety of enzymes
and factors that result in breakdown of myelin proteins, presentation of antigens to T and B …

… Five images per section were acquired at b = 0 sec/mm 2 , followed by five images at b =
1000 sec/mm 2 in six directions, for a total of 35 images per section. Imaging parameters were …

… Boxes in b demonstrate sites that were further imaged under … from the region outlined in a
and b. Note the decrease in NMDAR … from the region outlined in a and b for control mouse 1 (g) …

… The expression of the housekeeping gene β-actin was used as an internal control; (B)
Western blot assay showing the expression of hTERT protein at 48 hours after a 4 hour exposure …