User profiles for D L Kolson
 | Dennis KolsonProfessor of Neurology, University of Pennsylvania Verified email at pennmedicine.upenn.edu Cited by 13751 |
[HTML][HTML] HIV-associated neurocognitive disorder: pathogenesis and therapeutic opportunities
KA Lindl, DR Marks, DL Kolson… - Journal of neuroimmune …, 2010 - Springer
Human immunodeficiency virus type 1 (HIV) infection presently affects more that 40 million
people worldwide, and is associated with central nervous system (CNS) disruption in at least …
people worldwide, and is associated with central nervous system (CNS) disruption in at least …
Current understanding of HIV-associated neurocognitive disorders pathogenesis
P Gannon, MZ Khan, DL Kolson - Current opinion in neurology, 2011 - journals.lww.com
Prevention and treatment of HAND requires strategies aimed at suppressing CNS HIV
replication and effects of systemic and CNS inflammation in aging and substance-abusing HIV …
replication and effects of systemic and CNS inflammation in aging and substance-abusing HIV …
Age-related total gray matter and white matter changes in normal adult brain. Part I: volumetric MR imaging analysis
…, ML Rabin, LJ Mannon, DL Kolson - American journal …, 2002 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: A technique of segmenting total gray matter (GM) and total
white matter (WM) in human brain is now available. We investigated the effects of age and …
white matter (WM) in human brain is now available. We investigated the effects of age and …
Alzheimer's Aβ (1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells
DG Cook, MS Forman, JC Sung, S Leight, DL Kolson… - Nature medicine, 1997 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disorder involving the florid deposition of
vascular and cerebral plaques composed chiefly of amyloid β-peptide (Aβ) derived from …
vascular and cerebral plaques composed chiefly of amyloid β-peptide (Aβ) derived from …
Dimethyl fumarate modulation of immune and antioxidant responses: application to HIV therapy
The persistence of chronic immune activation and oxidative stress in human immunodeficiency
virus (HIV)-infected, antiretroviral drug-treated individuals are major obstacles to fully …
virus (HIV)-infected, antiretroviral drug-treated individuals are major obstacles to fully …
[HTML][HTML] Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1α is mediated by the chemokine receptor CXCR4
…, D Taub, P Baskar, M Greenberg, J Hoxie, DL Kolson… - Current Biology, 1998 - cell.com
CXCR4, a seven transmembrane domain G-protein-coupled receptor for the Cys–X–Cys
class of chemokines, is one of several chemokine receptors that can act as a co-receptor with …
class of chemokines, is one of several chemokine receptors that can act as a co-receptor with …
An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1
…, SA Gregory, H Friedman, DL Kolson… - Journal of …, 1992 - Am Soc Microbiol
We isolated and molecularly cloned a human immunodeficiency virus type 1 (HIV-1) strain (89.6)
which is unusual because it is both macrophage-tropic and extremely cytopathic in …
which is unusual because it is both macrophage-tropic and extremely cytopathic in …
[HTML][HTML] CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons
…, V DelVecchio, SC Peiper, J Hoxie, DL Kolson… - Current Biology, 1997 - cell.com
Background: Chemokines are a family of protiens that chemoattract and activate immune
cells by interacting with specific receptors on the surface of their targets. We have shown …
cells by interacting with specific receptors on the surface of their targets. We have shown …
Distinct effects in primary macrophages and lymphocytes of the human immunodeficiency virus type 1 accessory genes vpr, vpu, and nef: mutational analysis of a …
Macrophages and lymphocytes are the two main targets for productive HIV-1 infection in vivo.
To compare the effects of the "nonessential" HIV-1 accessory genes vpr, vpu, and nef on …
To compare the effects of the "nonessential" HIV-1 accessory genes vpr, vpu, and nef on …
An orphan seven-transmembrane domain receptor expressed widely in the brain functions as a coreceptor for human immunodeficiency virus type 1 and simian …
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