OBJECTIVE: The use of Web (ie Internet)-derived health information within the health care
encounter is rapidly increasing. In this article, an extensive review of the complex effects and …

The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS) pathogenesis
could be an important factor in the failure to identify disease-modifying therapy for this …

Previously thought to be nothing more than cellular debris, extracellular vesicles (EVs) are
now known to mediate physiological and pathological functions throughout the body. We now …

IL-1β is one of a family of proinflammatory cytokines thought to be involved in many acute
and chronic diseases. Although it is considered to participate in wound repair, no major role …

Missense mutations in the presenilin 1 (PS1) gene cause the most common form of dominant
early–onset familial Alzheimer's disease (FAD) 1,2 and are associated with increased …

The tight junctions found between cerebral vascular endothelial cells form the basis of the
blood–brain barrier. Breakdown of the blood–brain barrier is a feature of a variety of CNS …

DC Anthony, B. Ferguson, MK Matyzak, KM Miller, MM Esiri and VH Perry (1997)
Neuropathology and Applied Neurobiology23, 406–415 Differential matrix metalloproteinase …

One of the most important current scientific paradoxes is the economy with which nature
uses genes. In all higher animals studied, we have found many fewer genes than we would …

Cognitive dysfunction and reactive microglia are hallmarks of traumatic brain injury (TBI), yet
whether these cells contribute to cognitive deficits and secondary inflammatory pathology …

Multiple sclerosis is a disease of the central nervous system that is associated with leukocyte
recruitment and subsequent inflammation, demyelination and axonal loss. Endothelial …