User profiles for D. M. Beal
David BealPost-doctoral research fellow, University of Kent Verified email at kent.ac.uk Cited by 476 |
Molecular scaffolds using multiple orthogonal conjugations: applications in chemical biology and drug discovery
Heteromultifunctional scaffolds that harness sequential “click” reactions will find significant
utility in the areas of chemical biology and chemically enabled/enhanced biotherapeutics (“…
utility in the areas of chemical biology and chemically enabled/enhanced biotherapeutics (“…
[HTML][HTML] Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice
…, MD Selby, AD Brown, JW Coe, M Badland, DM Beal… - PloS one, 2013 - journals.plos.org
Anti-nicotine vaccines may aid smoking cessation via the induction of anti-nicotine antibodies
(Ab) which reduce nicotine entering the brain, and hence the associated reward. Ab …
(Ab) which reduce nicotine entering the brain, and hence the associated reward. Ab …
Click-enabled heterotrifunctional template for sequential bioconjugations
A heterotrifunctional template was developed that utilizes thiol–maleimide and click chemistries
(both copper-free and copper-mediated) to effect sequential biomolecule conjugations in …
(both copper-free and copper-mediated) to effect sequential biomolecule conjugations in …
The physical dimensions of amyloid aggregates control their infective potential as prion particles
R Marchante, DM Beal, N Koloteva-Levine, TJ Purton… - Elife, 2017 - elifesciences.org
10.7554/eLife.27109.001 Transmissible amyloid particles called prions are associated with
infectious prion diseases in mammals and inherited phenotypes in yeast. All amyloid …
infectious prion diseases in mammals and inherited phenotypes in yeast. All amyloid …
[HTML][HTML] Effect of bio-engineering on size, shape, composition and rigidity of bacterial microcompartments
Bacterial microcompartments (BMCs) are proteinaceous organelles that are found in a
broad range of bacteria and are composed of an outer shell that encases an enzyme cargo …
broad range of bacteria and are composed of an outer shell that encases an enzyme cargo …
Nutrient smuggling: Commensal gut bacteria‐derived extracellular vesicles scavenge vitamin B12 and related cobamides for microbe and host acquisition
R Juodeikis, E Jones, E Deery, DM Beal… - Journal of …, 2022 - Wiley Online Library
The processes by which bacteria proactively scavenge essential nutrients in crowded
environments such as the gastrointestinal tract are not fully understood. In this context, we …
environments such as the gastrointestinal tract are not fully understood. In this context, we …
A profile of cortical gray matter volume deficits characteristic of schizophrenia.
…, KO Lim, D Mathalon, L Marsh, DM Beal… - … cortex (New York …, 1998 - academic.oup.com
Quantitative magnetic resonance imaging (MRI) studies from our laboratory have reported
that patients with schizophrenia show a widespread cortical gray matter volume deficit, which …
that patients with schizophrenia show a widespread cortical gray matter volume deficit, which …
[HTML][HTML] Modification of bacterial microcompartments with target biomolecules via post-translational SpyTagging
Bacterial microcompartments (BMCs) are proteinaceous organelle-like structures formed
within bacteria, often encapsulating enzymes and cellular processes, in particular, allowing …
within bacteria, often encapsulating enzymes and cellular processes, in particular, allowing …
Brain dysmorphology in adults with congenital rubella plus schizophrenialike symptoms
KO Lim, DM Beal, RL Harvey Jr, T Myers, B Lane… - Biological …, 1995 - Elsevier
Brain morphology was quantified with magnetic resonance imaging (MRI) in adult patients
with congenital rubella who also had schizophrenialike symptoms. MRIs were compared with …
with congenital rubella who also had schizophrenialike symptoms. MRIs were compared with …
White matter MR hyperintensities in adult patients with congenital rubella.
B Lane, EV Sullivan, KO Lim, DM Beal… - American journal …, 1996 - Am Soc Neuroradiology
… , Beal DM, Harvey RL Jr, et al. Brain dysmorphology in adults with congenital rubella plus
schizophrenia-like symptoms. Biol Psychiatry 1995;37:764 –776 4. Lim KO, Harris D, Beal DM, …
schizophrenia-like symptoms. Biol Psychiatry 1995;37:764 –776 4. Lim KO, Harris D, Beal DM, …