Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

…, A Andreadis, J Snowden, D Craufurd, D Neary… - Nature, 1998 - nature.com
Thirteen families have been described with an autosomal dominantly inherited dementia
named frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) 1 , 2 , 3 …

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

…, I Malone, H Crawford, D Whitehead… - The Lancet …, 2017 - thelancet.com
Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin
gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis …

Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data

…, BR Leavitt, RAC Roos, A Durr, D Craufurd… - The Lancet …, 2009 - thelancet.com
Background Huntington's disease (HD) is an autosomal dominant, fully penetrant,
neurodegenerative disease that most commonly affects adults in mid-life. Our aim was to identify …

Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month …

…, C Frost, H Johnson, D Craufurd… - The Lancet …, 2013 - thelancet.com
Background TRACK-HD is a multinational prospective observational study of Huntington's
disease (HD) that examines clinical and biological findings of disease progression in …

Phenotypic characterization of individuals with 30–40 CAG repeats in the Huntington disease (HD) gene reveals HD cases with 36 repeats and apparently normal …

…, M Connarty, D Craufurd, A Curtis, D Curtis… - American journal of …, 1996 - ncbi.nlm.nih.gov
Abnormal CAG expansions in the IT-15 gene are associated with Huntington disease (HD).
In the diagnostic setting it is necessary to define the limits of the CAG size ranges on normal …

Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis

…, H Johnson, SL Hicks, C Kennard, D Craufurd… - The Lancet …, 2011 - thelancet.com
Background TRACK-HD is a prospective observational study of Huntington's disease (HD)
that examines disease progression in premanifest individuals carrying the mutant HTT gene …

[HTML][HTML] Targeting huntingtin expression in patients with Huntington's disease

…, C Saft, RA Barker, NF Blair, D Craufurd… - … England Journal of …, 2019 - Mass Medical Soc
Background Huntington’s disease is an autosomal-dominant neurodegenerative disease
caused by CAG trinucleotide repeat expansion in HTT, resulting in a mutant huntingtin protein. …

Unawareness of deficits in Huntington's disease

EJ Sitek, JC Thompson, D Craufurd… - Journal of …, 2014 - content.iospress.com
People with Huntington’s disease (HD) may show reduced awareness of physical and
mental changes in themselves. This article reviews the evidence for loss of awareness (…

Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data

…, G Owen, R Jones, H Johnson, D Craufurd… - The Lancet …, 2012 - thelancet.com
Background TRACK-HD is a prospective observational biomarker study in premanifest and
early Huntington's disease (HD). In this report we define a battery of potential outcome …

[HTML][HTML] The electric and magnetic field instrument suite and integrated science (EMFISIS) on RBSP

…, SR Bounds, M Chutter, J Connerney, D Crawford… - Space Science …, 2013 - Springer
… Such codes require accurate specification of the rate of radial diffusion D LL , pitch angle
scattering D αα , and energy (or momentum) diffusion D EE . Each diffusion coefficient requires …