Analysis of shared heritability in common disorders of the brain

…, Y Kamatani, C Berr, L Letenneur, D Hannequin… - Science, 2018 - science.org
INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …

Voice onset time in aphasia, apraxia of speech and dysarthria: a review

…, M Jan, F Eustache, D Hannequin - Clinical linguistics & …, 2000 - Taylor & Francis
Voice onset time (VOT) is an objective temporal acoustic parameter defined as the time
between the release of the oral constriction for plosive production and the onset of vocal fold …

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

…, G Annoni, D Seripa, D Galimberti, D Hannequin… - Nature …, 2009 - nature.com
The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed
susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we conducted a …

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

A Rovelet-Lecrux, D Hannequin, G Raux, NL Meur… - Nature …, 2006 - nature.com
… (d,e) FISH analysis from peripheral blood lymphocytes of a patient from family F229. (d)
Interphase cells. Hybridization signals were generated using simultaneously the BAC clone …

[PDF][PDF] Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum

D Campion, C Dumanchin, D Hannequin… - The American Journal of …, 1999 - cell.com
To determine the prevalence of early-onset Alzheimer disease (EOAD) and of autosomal
dominant forms of EOAD (ADEOAD), we performed a population-based study in the city of …

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

…, ND Price, D Hannequin, A Frank-García, D Levy… - Nature …, 2017 - nature.com
We identified rare coding variants associated with Alzheimer's disease in a three-stage case–control
study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-…

APOE and Alzheimer disease: a major gene with semi-dominant inheritance

E Genin, D Hannequin, D Wallon, K Sleegers… - Molecular …, 2011 - nature.com
… Where P i,s (D)=I i,s is the incidence rate for individuals of sex s in age group i,, P i (G=g∣D)
is the prevalence of genotype g among those who develop the disease in age category i (…

A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease

…, C Mummery, GM Surti, D Hannequin, D Wallon… - Nature medicine, 2021 - nature.com
Dominantly inherited Alzheimer’s disease (DIAD) causes predictable biological changes
decades before the onset of clinical symptoms, enabling testing of interventions in the …

[HTML][HTML] APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases

…, J Pariente, C Paquet, D Hannequin, D Campion… - PLoS …, 2017 - journals.plos.org
Background Amyloid protein precursor (APP), presenilin-1 (PSEN1), and presenilin-2 (PSEN2)
mutations cause autosomal dominant forms of early-onset Alzheimer disease (AD-EOAD)…

[HTML][HTML] A polymorphism in CALHM1 influences Ca2+ homeostasis, Aβ levels, and Alzheimer's disease risk

…, D Hannequin, F Pasquier, D Galimberti… - Cell, 2008 - cell.com
Alzheimer's disease (AD) is a genetically heterogeneous disorder characterized by early
hippocampal atrophy and cerebral amyloid-β (Aβ) peptide deposition. Using TissueInfo to …