Prodrugs are bioreversible derivatives of drug molecules that undergo an enzymatic and/or
chemical transformation in vivo to release the active parent drug, which can then exert the …

Publications pushing the “innovation ecosystem” meme have added valuable dimensions to
the economic development discussion. The phrase has captured the imagination of policy …

HER2 is an established therapeutic target in a large subset of women with breast cancer; a
variety of agents including trastuzumab, pertuzumab, lapatinib, neratinib and trastuzumab …

Background Trastuzumab emtansine (T-DM1) is an antibody–drug conjugate incorporating
the human epidermal growth factor receptor 2 (HER2)–targeted antitumor properties of …

Background Patients with a germline BRCA1 or BRCA2 mutation make up a small
subgroup of those with metastatic pancreatic cancer. The poly(adenosine diphosphate–ribose) …

… Mean 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) and parathyroid hormone levels were also
… were sustained thereafter; 1,25(OH)2D 3 and parathyroid hormone concentrations followed …

Objective: Although mindfulness-based therapy has become a popular treatment, little is
known about its efficacy. Therefore, our objective was to conduct an effect size analysis of this …

Background Gene-expression–profiling studies of primary breast tumors performed by different
laboratories have resulted in the identification of a number of distinct prognostic profiles, …

Thermal and electrochemical processes in a 1000mAh lithium-ion pouch cell with a graphite
anode and a Li x CoO 2 cathode during a safety test are examined. In overcharge tests, the …

Background Validation of a novel gene expression signature in independent data sets is a
critical step in the development of a clinically useful test for cancer patient risk-stratification. …