Something silent this way forms: the functional organization of the repressive nuclear compartment

JCR Politz, D Scalzo, M Groudine - Annual review of cell and …, 2013 - annualreviews.org
The repressive compartment of the nucleus is comprised primarily of telomeric and centromeric
regions, the silent portion of ribosomal RNA genes, the majority of transposable element …

The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote

D Schübeler, DM MacAlpine, D Scalzo… - Genes & …, 2004 - genesdev.cshlp.org
The covalent modification of nucleosomal histones has emerged as a major determinant of
chromatin structure and gene activity. To understand the interplay between various histone …

Normal-pressure hydrocephalus: evaluation with cerebrospinal fluid flow measurements at MR imaging.

WG Bradley Jr, D Scalzo, J Queralt, WN Nitz… - Radiology, 1996 - pubs.rsna.org
PURPOSE: To evaluate magnetic resonance (MR) imaging-based quantitative phase-contrast
cerebrospinal fluid (CSF) velocity imaging for prediction of successful shunting in patients …

Genome-wide DNA replication profile for Drosophila melanogaster: a link between transcription and replication timing

D Schübeler, D Scalzo, C Kooperberg… - Nature …, 2002 - nature.com
… S phase 8 , our analysis of the complete D. melanogaster euchromatin showed no such trend
for … of DNA replication in D. melanogaster Kc cells have established that D. melanogaster …

[HTML][HTML] TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends

…, JMR Danielsen, CA Lucas, EL Rice, D Scalzo… - Nature …, 2014 - nature.com
Telomeres protect the ends of linear genomes, and the gradual loss of telomeres is associated
with cellular ageing. Telomere protection involves the insertion of the 3′ overhang …

HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics

…, J Collado, F Yue, JC Ritland Politz, LJ Tait, D Scalzo… - Elife, 2021 - elifesciences.org
Chromatin, which consists of DNA and associated proteins, contains genetic information and
is a mechanical component of the nucleus. Heterochromatic histone methylation controls …

DNA replication-timing analysis of human chromosome 22 at high resolution and different developmental states

EJ White, O Emanuelsson, D Scalzo… - Proceedings of the …, 2004 - National Acad Sciences
Duplication of the genome during the S phase of the cell cycle does not occur simultaneously;
rather, different sequences are replicated at different times. The replication timing of …

The redundancy of the mammalian heterochromatic compartment

JCR Politz, D Scalzo, M Groudine - Current opinion in genetics & …, 2016 - Elsevier
Two chromatin compartments are present in most mammalian cells; the first contains
primarily euchromatic, early replicating chromatin and the second, primarily late-replicating …

Overlapping thin-section fast spin-echo MR of the large vestibular aqueduct syndrome.

…, R Allen, JL Parkin, D Scalzo - American journal …, 1997 - Am Soc Neuroradiology
PURPOSE To evaluate a high-resolution, thin-section fast spin-echo MR imaging technique
of the inner ear to identify the large vestibular aqueduct syndrome seen on temporal bone …

Transcriptional enhancers act in cis to suppress position-effect variegation.

…, W Magis, S Fiering, J Eidemiller, D Scalzo… - Genes & …, 1996 - genesdev.cshlp.org
We have examined the basis of enhancer effects on gene expression by altering the action
of enhancers on expression of a stably integrated reporter gene. We used two distinct …