OBJECTIVE: This article examines the foundation of β-cell failure in type 2 diabetes (T2D)
and suggests areas for future research on the underlying mechanisms that may lead to …

Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs. Our
understanding of the genesis of this injury and of potential interventions to prevent, limit, or …

Mapping by admixture linkage disequilibrium (LD) detected strong association between
nonmuscle myosin heavy chain 9 gene (MYH9) variants on chromosome 22 and nondiabetic …

African Americans have higher rates of kidney disease than European Americans. Here, we
show that, in African Americans, focal segmental glomerulosclerosis (FSGS) and …

We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130
European-descent individuals (9% cases), after imputation to high-density reference panels. …

The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …

We report the construction of a linkage map of the human genome, based on the pattern of
inheritance of 403 polymorphic loci, including 393 RFLPs, in a panel of DNAs from 21 three-…

The increased burden of chronic kidney and end-stage kidney diseases (ESKD) in
populations of African ancestry has been largely unexplained. To identify genetic variants …

Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …

Height is a highly heritable, classic polygenic trait with approximately 700 common associated
variants identified through genome-wide association studies so far. Here, we report 83 …