User profiles for Dennis L. Kolson
 | Dennis KolsonProfessor of Neurology, University of Pennsylvania Verified email at pennmedicine.upenn.edu Cited by 13751 |
Age-related total gray matter and white matter changes in normal adult brain. Part I: volumetric MR imaging analysis
…, ML Rabin, LJ Mannon, DL Kolson - American journal …, 2002 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: A technique of segmenting total gray matter (GM) and total
white matter (WM) in human brain is now available. We investigated the effects of age and …
white matter (WM) in human brain is now available. We investigated the effects of age and …
Alzheimer's Aβ (1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells
DG Cook, MS Forman, JC Sung, S Leight, DL Kolson… - Nature medicine, 1997 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disorder involving the florid deposition of
vascular and cerebral plaques composed chiefly of amyloid β-peptide (Aβ) derived from …
vascular and cerebral plaques composed chiefly of amyloid β-peptide (Aβ) derived from …
[HTML][HTML] Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1α is mediated by the chemokine receptor CXCR4
…, D Taub, P Baskar, M Greenberg, J Hoxie, DL Kolson… - Current Biology, 1998 - cell.com
CXCR4, a seven transmembrane domain G-protein-coupled receptor for the Cys–X–Cys
class of chemokines, is one of several chemokine receptors that can act as a co-receptor with …
class of chemokines, is one of several chemokine receptors that can act as a co-receptor with …
[HTML][HTML] HIV-associated neurocognitive disorder: pathogenesis and therapeutic opportunities
KA Lindl, DR Marks, DL Kolson… - Journal of neuroimmune …, 2010 - Springer
Human immunodeficiency virus type 1 (HIV) infection presently affects more that 40 million
people worldwide, and is associated with central nervous system (CNS) disruption in at least …
people worldwide, and is associated with central nervous system (CNS) disruption in at least …
[HTML][HTML] CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons
…, V DelVecchio, SC Peiper, J Hoxie, DL Kolson… - Current Biology, 1997 - cell.com
Background: Chemokines are a family of protiens that chemoattract and activate immune
cells by interacting with specific receptors on the surface of their targets. We have shown …
cells by interacting with specific receptors on the surface of their targets. We have shown …
Current understanding of HIV-associated neurocognitive disorders pathogenesis
P Gannon, MZ Khan, DL Kolson - Current opinion in neurology, 2011 - journals.lww.com
Prevention and treatment of HAND requires strategies aimed at suppressing CNS HIV
replication and effects of systemic and CNS inflammation in aging and substance-abusing HIV …
replication and effects of systemic and CNS inflammation in aging and substance-abusing HIV …
Distinct effects in primary macrophages and lymphocytes of the human immunodeficiency virus type 1 accessory genes vpr, vpu, and nef: mutational analysis of a …
Macrophages and lymphocytes are the two main targets for productive HIV-1 infection in vivo.
To compare the effects of the "nonessential" HIV-1 accessory genes vpr, vpu, and nef on …
To compare the effects of the "nonessential" HIV-1 accessory genes vpr, vpu, and nef on …
An orphan seven-transmembrane domain receptor expressed widely in the brain functions as a coreceptor for human immunodeficiency virus type 1 and simian …
Both CD4 and an appropriate coreceptor are necessary for infection of cells by human
immunodeficiency virus type 1 (HIV-1) and most strains of HIV-2. The chemokine receptors CCR5 …
immunodeficiency virus type 1 (HIV-1) and most strains of HIV-2. The chemokine receptors CCR5 …
[HTML][HTML] Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system
HIV-associated neurocognitive disorder (HAND), characterized by a wide spectrum of
behavioral, cognitive, and motor dysfunctions, continues to affect approximately 50 % of HIV(+) …
behavioral, cognitive, and motor dysfunctions, continues to affect approximately 50 % of HIV(+) …
Brain atrophy in relapsing-remitting multiple sclerosis and secondary progressive multiple sclerosis: longitudinal quantitative analysis
PURPOSE: To determine annual rates of volumetric changes in the whole-brain parenchyma
of patients with relapsing-remitting and secondary progressive multiple sclerosis (MS) and …
of patients with relapsing-remitting and secondary progressive multiple sclerosis (MS) and …