Importance Oncolytic viruses (OVs) are emerging as important agents in cancer treatment.
Oncolytic viruses offer the attractive therapeutic combination of tumor-specific cell lysis …

ONYX-015 is an oncolytic virus untested as a treatment for malignant glioma. The NABTT
CNS Consortium conducted a dose-escalation trial of intracerebral injections of ONYX-015. …

Background The tumor microenvironment is being increasingly recognized as an important
determinant of tumor progression as well as of therapeutic response. We investigated …

Although the cytotoxic effects of viruses are usually viewed in terms of pathogenicity, it is
possible to harness this activity for therapeutic purposes. Viral genomes are highly versatile, …

Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …

Neoantigens, which are derived from tumour-specific protein-coding mutations, are exempt
from central tolerance, can generate robust immune responses 1 , 2 and can function as …

microRNAs are noncoding RNAs inhibiting expression of numerous target genes, and a few
have been shown to act as oncogenes or tumor suppressors. We show that microRNA-7 (…

MicroRNAs (miR) show characteristic expression signatures in various cancers and can
profoundly affect cancer cell behavior. We carried out miR expression profiling of human …

Targeted therapy against the programmed cell death ligand-1 (PD-L1) blockade holds
considerable promise for the treatment of different tumor types; however, little effect has been …

Results First, we sought to demonstrate that ETR expression correlated with increases in
internalized Tf-MION. For these experiments, we implanted nude mice with both stably …