The emerging relationship between interstitial fluid–cerebrospinal fluid exchange, amyloid-β, and sleep

EL Boespflug, JJ Iliff - Biological psychiatry, 2018 - Elsevier
Amyloid-β (Aβ) plaques are a key histopathological hallmark of Alzheimer’s disease (AD),
and soluble Aβ species are believed to play an important role in the clinical development of …

Brain-mapping techniques for evaluating poststroke recovery and rehabilitation: a review

JC Eliassen, EL Boespflug, M Lamy… - Topics in stroke …, 2008 - Taylor & Francis
Brain-mapping techniques have proven to be vital in understanding the molecular, cellular,
and functional mechanisms of recovery after stroke. This article briefly summarizes the …

Concord grape juice supplementation and neurocognitive function in human aging

R Krikorian, EL Boespflug, DE Fleck… - Journal of agricultural …, 2012 - ACS Publications
Polyphenol compounds found in berry fruits, in particular flavonoids, have been associated
with health benefits including improvement in cognition and neuronal function with aging. …

Enhanced neural activation with blueberry supplementation in mild cognitive impairment

EL Boespflug, JC Eliassen, JA Dudley… - Nutritional …, 2018 - Taylor & Francis
Objectives: Preclinical studies have shown that blueberry supplementation can improve
cognitive performance and neural function in aged animals and have identified associations …

[HTML][HTML] Fish oil supplementation increases event-related posterior cingulate activation in older adults with subjective memory impairment

EL Boespflug, RK McNamara, JC Eliassen… - The Journal of nutrition …, 2016 - Elsevier
Objective To determine the effects of long-chain omega-3 (LCn-3) fatty acids found in fish oil,
including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on cortical blood …

Venous collagenosis as pathogenesis of white matter hyperintensity

…, SE Black, N Roese, H Dodge, EL Boespflug… - Annals of …, 2022 - Wiley Online Library
Objective Periventricular white matter hyperintensities (pvWMHs) are commonly observed on
MRI in older individuals and are associated with cognitive and motor decline. The etiology …

Baseline NAWM structural integrity and CBF predict periventricular WMH expansion over time

N Promjunyakul, HH Dodge, D Lahna, EL Boespflug… - Neurology, 2018 - AAN Enterprises
Objective We aimed to describe and compare baseline cerebral blood flow (CBF) and
microstructural characteristics of normal-appearing white matter (NAWM) within the vulnerable …

Improved cognitive-cerebral function in older adults with chromium supplementation

R Krikorian, JC Eliassen, EL Boespflug… - Nutritional …, 2010 - Taylor & Francis
Insulin resistance is implicated in the pathophysiological changes associated with Alzheimer's
disease, and pharmaceutical treatments that overcome insulin resistance improve …

Targeted assessment of enlargement of the perivascular space in Alzheimer's disease and vascular dementia subtypes implicates astroglial involvement specific to …

EL Boespflug, MJ Simon, E Leonard… - Journal of …, 2018 - content.iospress.com
… All vessel-wise quantification was completed by a research assistant (EL) blind to clinical
group status. For each subject, the perivascular space was evaluated at ten large caliber (…

MR imaging–based multimodal autoidentification of perivascular spaces (mMAPS): automated morphologic segmentation of enlarged perivascular spaces at clinical …

EL Boespflug, DL Schwartz, D Lahna, J Pollock, JJ Iliff… - Radiology, 2018 - pubs.rsna.org
Purpose To describe a fully automated segmentation method that yields object-based
morphologic estimates of enlarged perivascular spaces (ePVSs) in clinical-field-strength (3.0-T) …