Diagnostic methods and treatment options for focal cortical dysplasia

…, J Gotman, F Chassoux, P Ryvlin, F Bartolomei… - …, 2015 - Wiley Online Library
Our inability to adequately treat many patients with refractory epilepsy caused by focal cortical
dysplasia ( FCD ), surgical inaccessibility and failures are significant clinical drawbacks. …

French guidelines on stereoelectroencephalography (SEEG)

…, P Bourdillon, H Catenoix, F Chassoux… - Neurophysiologie …, 2018 - Elsevier
Stereoelectroencephalography (SEEG) was designed and developed in the 1960s in
France by J. Talairach and J. Bancaud. It is an invasive method of exploration for drug-resistant …

[HTML][HTML] Histopathological findings in brain tissue obtained during epilepsy surgery

…, JC Baayen, E Aronica, F Chassoux… - … England Journal of …, 2017 - Mass Medical Soc
Background Detailed neuropathological information on the structural brain lesions underlying
seizures is valuable for understanding drug-resistant focal epilepsy. Methods We report …

Stereoelectroencephalography in focal cortical dysplasia: a 3D approach to delineating the dysplastic cortex

F Chassoux, B Devaux, E Landré, B Turak, F Nataf… - Brain, 2000 - academic.oup.com
Focal cortical dysplasia (FCD) is an increasingly recognized cause of intractable epilepsy.
Surgical data suggest that the dysplastic cortex should be removed to obtain freedom from …

Planning and management of SEEG

F Chassoux, V Navarro, H Catenoix, L Valton… - Neurophysiologie …, 2018 - Elsevier
… On the left side, one electrode targeted the ACG, [F’] symmetric to [F]. The ictal discharge
was characterized by a low voltage fast activity following a burst of rapid rhythms starting in the …

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood–brain barrier

…, F Dutheil, RJ Weaver, F Chassoux… - Journal of …, 2008 - Wiley Online Library
We have established the expression patterns of the genes encoding ATP‐binding cassette (ABC)
transporters and cytochromes P450 (CYPs) at the adult human blood–brain barrier (…

Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study

…, CG Bien, I Bodi, H Catenoix, F Chassoux… - The Lancet …, 2020 - thelancet.com
Background Surgery is a widely accepted treatment option for drug-resistant focal epilepsy.
A detailed analysis of longitudinal postoperative seizure outcomes and use of antiepileptic …

FDG-PET improves surgical outcome in negative MRI Taylor-type focal cortical dysplasias

F Chassoux, S Rodrigo, F Semah, F Beuvon, E Landre… - Neurology, 2010 - AAN Enterprises
Objective: To determine the diagnostic accuracy and prognostic value of 18 FDG-PET in a
recent series of patients operated for intractable partial epilepsy associated with histologically …

Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels

…, S Yousif, S Dauchy, A Jacob, F Chassoux… - Molecular …, 2011 - ACS Publications
We have investigated the transcriptomic and/or proteomic patterns of 71 solute carrier (SLC)
and organic solute (OST) transporters, 34 ATP-binding cassette (ABC) transporters, and 51 …

Familial focal epilepsy with focal cortical dysplasia due to DEPDC5 mutations

…, F Andermann, E Leguern, F Chassoux… - Annals of …, 2015 - Wiley Online Library
Objective The DEPDC5 (DEP domain‐containing protein 5) gene, encoding a repressor of
the mTORC1 signaling pathway, has recently emerged as a major gene mutated in familial …