Importance The procalcitonin (PCT) assay is an accurate screening test for identifying
invasive bacterial infection (IBI); however, data on the PCT assay in very young infants are …

Results Among 108 patients treated with eculizumab, 38 patients (nine children and 29
adults) discontinued eculizumab (median treatment duration of 17.5 months). Twenty-one …

The optimal duration of eculizumab treatment in patients with atypical hemolytic uremic
syndrome (aHUS) remains poorly defined. We conducted a prospective national multicenter open…

Background— Little is known about the risk factors for cervical artery dissection (CEAD), a
major cause of ischemic stroke (IS) in young adults. Hypertension, diabetes mellitus, smoking, …

Bartter syndrome type 3 is a clinically heterogeneous hereditary salt-losing tubulopathy caused
by mutations of the chloride voltage-gated channel Kb gene (CLCNKB), which encodes …

Objective: Several small to medium-sized studies indicated a link between cervical artery
dissection (CeAD) and migraine. Migrainous CeAD patients were suggested to have different …

Prenatal forms of autosomal dominant polycystic kidney disease (ADPKD) are rare but can
be recurrent in some families, suggesting a common genetic modifying background. Few …

BACKGROUND Proteinuria is considered an unfavorable clinical condition that accelerates
renal and cardiovascular disease. However, it is not clear whether all forms of proteinuria …

Background Recommendations for management of Finnish-type congenital nephrotic
syndrome (CNS) followed by many teams include daily albumin infusions, early bilateral …

Background The pathophysiology of the leading cause of pediatric acute nephritis, acute
postinfectious GN, including mechanisms of the pathognomonic transient complement …