Heterozygous mutation of IDH1 in cancers modifies IDH1 enzymatic activity, reprogramming
metabolite flux and markedly elevating 2-hydroxyglutarate (2-HG). Here, we found that 2-…

Meningiomas are the most common type of primary central nervous system tumors.
Approximately, 80% of meningiomas are classified by the World Health Organization (WHO) as …

… (f) Immunofluorescence detection of the expression and location of NCL in U87 and NHA
cells. (g) Immunofluorescence detection of FITC-AS1411 (green) and NCL (red) co-…

BACKGROUND AND PURPOSE: Radiographic assessment of cerebral metastasis after
stereotactic radiosurgery remains a major challenge in neuro-oncology. It is often difficult to …

Approximately 1-5% of patients with cerebral metastasis and~ 40% of patients with primary
brain tumors suffer from hydrocephalus. These patients often exhibit a poor prognosis. The …

Despite the current standard of multimodal management, glioblastoma (GBM) inevitably
recurs and effective therapy is not available for recurrent disease. A subset of tumor cells with …

OBJECTIVES The management of patients affected by lung cancer requires the expertise of
specialists from different disciplines. Although the advantages of multidisciplinary team …

… Arrows point to blood vessels (F). CD34 staining reveals tortuous and dilated vasculature
at the tumor periphery in the xenografts ( G , left panel). CD31 staining of the patient section …

Background Higher-grade meningiomas (HGMs; World Health Organization grades II and III)
pose a clinical problem due to high recurrence rates and the absence of effective therapy. …

Introduction Granular cell tumors (GCTs) of the infundibulum are rare in practice and literature,
resulting in a lack of evidence-based standard of care. We present two characteristic …