Background: In addition to nonmodifiable genetic risk factors, potentially modifiable factors
such as hypertension, hyperlipidemia and environmental exposures have been identified as …

Alzheimer's disease (AD) is the most common form of neurodegenerative dementia and
affects up to 15 million people worldwide. Although no single cause of AD has been identified, …

Master layout sheet Page 1 436 Early-onset familial Alzheimer’s disease (EOFAD) is a condition
characterized by dementia onset at a relatively young age (before 65 years of age) and …

Several families have been reported with autosomal-dominant frontotemporal dementia (FTD)
and amyotrophic lateral sclerosis (ALS), genetically linked to chromosome 9p21. Here, we …

Dominantly inherited Alzheimer’s disease (DIAD) causes predictable biological changes
decades before the onset of clinical symptoms, enabling testing of interventions in the …

Null mutations in the progranulin gene ( PGRN ) were recently reported to cause tau-negative
frontotemporal dementia linked to chromosome 17. We assessed the genetic contribution …

Objective To identify single-nucleotide polymorphisms (SNPs) associated with risk and age
at onset of Alzheimer disease (AD) in a genomewide association study of 469 438 SNPs. …

Background The cerebrospinal fluid (CSF) biomarkers amyloid beta 1–42, total tau, and
phosphorylated tau are used increasingly for Alzheimer's disease (AD) research and patient …

… (TX buffer) and centrifuged at 180,000 3 g for 30 min at 4 C. Pellets were again suspended
in TX buffer supplemented with 30% sucrose and centrifuged at 180,000 3 g for 30 min at 4 …

Background Frontotemporal dementia (FTD) is a complex disorder characterised by a broad
range of clinical manifestations, differential pathological signatures, and genetic variability. …