Background Among patients with non–small-cell lung cancer (NSCLC), data on intratumor
heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. …

The early detection of relapse following primary surgery for non-small-cell lung cancer and
the characterization of emerging subclones, which seed metastatic sites, might offer new …

Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through
human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the …

… , PD-1, and TIM-3 (Figure 1G). The percentage of cells expressing these molecules appeared
higher … À and CD8+ T cell subsets also expressed these molecules (Figure 1G), the level of …

CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as
a target for cancer immunotherapy. However, anti-CD25 antibodies have displayed limited …

The importance of intratumour genetic and functional heterogeneity is increasingly recognised
as a driver of cancer progression and survival outcome. Understanding how tumour …

… The other four patients had no risk factors, but a mean cumulative dose of 6.5 g. Seven
patients, who did not have a NASH-like pattern of injury, had a mean cumulative dose of 3.8 g. …

Background Radical surgery via total mesorectal excision might not be the optimal first-line
treatment for early-stage rectal cancer. An organ-preserving strategy with selective total …

Background: Tumor levels of steroid hormone receptors, a factor used to select adjuvant
treatment for early-stage breast cancer, are currently determined with immunohistochemical …

We present 1470 surgical resections for thymoma identified in the pathology files of 14
institutions from 11 countries with the purpose of determining and correlating a simplified …