Obesity is characterized by increased storage of fatty acids in an expanded adipose tissue
mass and is closely associated with the development of insulin resistance in peripheral …

The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …

The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP ratios. …

We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized
by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the …

The functional and molecular similarities and distinctions between human and murine astrocytes
are poorly understood. Here, we report the development of an immunopanning method …

Ustilago maydis is a ubiquitous pathogen of maize and a well-established model organism
for the study of plant–microbe interactions 1 . This basidiomycete fungus does not use …

CD47, a “don't eat me” signal for phagocytic cells, is expressed on the surface of all human
solid tumor cells. Analysis of patient tumor and matched adjacent normal (nontumor) tissue …

A case‐control study was performed to estimate the relative risk of developing prostate cancer
for men with a positive family history. Extensive cancer pedigrees were obtained on 691 …

Although interleukin-6 (IL-6) has been associated with insulin resistance, little is known
regarding the effects of IL-6 on insulin sensitivity in humans in vivo. Here, we show that IL-6 …

Objective. —To determine the long-term effectiveness of comprehensive support and
counseling for spouse-caregivers and families in postponing or preventing nursing home …