Cerebral edema contributes significantly to morbidity and death associated with many common
neurological disorders. However, current treatment options are limited to hyperosmolar …

Background and Purpose—Intracerebral hemorrhage (ICH) constitutes 10% to 15% of all
strokes and remains without a treatment of proven benefit. Despite several existing outcome …

The heterogeneity of traumatic brain injury (TBI) is considered one of the most significant
barriers to finding effective therapeutic interventions. In October, 2007, the National Institute of …

Blood-derived biomarkers for brain and spinal cord diseases are urgently needed. The
introduction of highly sensitive immunoassays led to a rapid increase in the number of potential …

Aquaporin‐4 (AQP4) is the major water channel in the brain, expressed predominantly in
astroglial cell membranes. Initial studies in AQP4‐deficient mice showed reduced cellular brain …

Traumatic brain injury (TBI) has the highest incidence of all common neurological disorders,
and poses a substantial public health burden. TBI is increasingly documented not only as …

Severe traumatic brain injury remains a major health-care problem worldwide. Although
major progress has been made in understanding of the pathophysiology of this injury, this has …

1 Guan W, Ni Z, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N
Engl J Med 2020; published online Feb 28. DOI: 10.1056/NEJMoa2002032. 2 Hopkins C, …

Aquaporin-4, the major water-selective channel in astroglia throughout the central nervous
system, facilitates water movement into and out of the brain. Here, we identify a novel role for …

Mild Traumatic Brain Injury (mTBI), or concussion, is a major public health concern. There is
controversy in the literature regarding the true incidence of postconcussion syndrome (PCS)…