In the past 8 years, both the International Working Group (IWG) and the US National Institute
on Aging–Alzheimer's Association have contributed criteria for the diagnosis of Alzheimer's …

Although the prevalence of dementia continues to increase worldwide, incidence in the
western world might have decreased as a result of better vascular care and improved brain …

Structural imaging based on magnetic resonance is an integral part of the clinical assessment
of patients with suspected Alzheimer dementia. Prospective data on the natural history of …

The APOE ε4 allele is a risk factor for late-life pathological changes that is also associated
with anatomical and functional brain changes in middle-aged and elderly healthy subjects. …

Alzheimer's disease (AD) is the leading cause of dementia, and because the primary risk
factor for AD is old age, the prevalence of the disease is increasing dramatically with ageing …

During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD)
considering the disease as a continuum. Thanks to evolving biomarker research and …

Importance Cerebral amyloid-β aggregation is an early pathological event in Alzheimer
disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid …

In 2018, the US National Institute on Aging and the Alzheimer's Association proposed a
purely biological definition of Alzheimer's disease that relies on biomarkers. Although the …

Biomarkers have become an essential component of Alzheimer disease (AD) research and
because of the pervasiveness of AD pathology in the elderly, the same biomarkers are used …

The current conceptualization of Alzheimer disease (AD) is driven by the amyloid hypothesis,
in which a deterministic chain of events leads from amyloid deposition and then tau …