User profiles for H. Brashear

Helene Brashear

W2O Group
Verified email at w2ogroup.com
Cited by 1714

Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup

…, W Thies, MM Bednar, RS Black, HR Brashear… - Alzheimer's & …, 2011 - Elsevier
Amyloid imaging related abnormalities (ARIA) have now been reported in clinical trials with
multiple therapeutic avenues to lower amyloid-β burden in Alzheimer’s disease (AD). In …

Can we prevent Alzheimer's disease? Secondary “prevention” trials in Alzheimer's disease

MC Carrillo, HR Brashear, V Logovinsky, JM Ryan… - Alzheimer's & …, 2013 - Elsevier
Current research including the basic biology of Alzheimer's disease (AD) provides a
foundation to explore whether our current state of knowledge is sufficient to initiate prevention …

[HTML][HTML] Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease

…, E Yuen, R Black, HR Brashear - … England Journal of …, 2014 - Mass Medical Soc
Background Bapineuzumab, a humanized anti–amyloid-beta monoclonal antibody, is in
clinical development for the treatment of Alzheimer's disease. Methods We conducted two …

A controlled trial of tacrine in Alzheimer's disease

…, J Caress, R Shatz, GR Hanna, HR Brashear… - Jama, 1992 - jamanetwork.com
Objective. —To compare efficacy and safety of tacrine hydrochloride with placebo in
patients with probable Alzheimer's disease. Design. —A 12-week, double-blind, placebo-controlled, …

Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis

…, Y Lu, E Liu, KM Gregg, HR Brashear… - The Lancet …, 2012 - thelancet.com
Background Amyloid-related imaging abnormalities (ARIA) have been reported in patients
with Alzheimer's disease treated with bapineuzumab, a humanised monoclonal antibody …

American sign language recognition with the kinect

Z Zafrulla, H Brashear, T Starner, H Hamilton… - Proceedings of the 13th …, 2011 - dl.acm.org
We investigate the potential of the Kinect depth-mapping camera for sign language recognition
and verification for educational games for deaf children. We compare a prototype Kinect-…

Cholinergic and GABAergic afferents to the olfactory bulb in the rat with special emphasis on the projection neurons in the nucleus of the horizontal limb of the …

L Zaborszky, J Carlsen, HR Brashear… - Journal of …, 1986 - Wiley Online Library
We have examined the location of cholinergic and GABAergic neurons that project to the rat
main olfactory bulb by combining choline acetyltransferase (ChAT) and glutamic acid …

Safety and efficacy of galantamine in subjects with mild cognitive impairment

…, L Truyen, AJ Mayorga, D Wang, HR Brashear… - Neurology, 2008 - AAN Enterprises
Objective: To assess the safety of galantamine in subjects with mild cognitive impairment (MCI),
the ability of galantamine to benefit cognition and global functioning in subjects with MCI…

Antibodies to cerebellar Purkinje cells in patients with paraneoplastic cerebellar degeneration and ovarian carcinoma

JE Greenlee, HR Brashear - … of Neurology: Official Journal of the …, 1983 - Wiley Online Library
Sera from 2 patients with ovarian carcinoma and paraneoplastic cerebellar degeneration
confirmed postmortem were reacted with frozen sections of human cerebellum and stained …

[HTML][HTML] Bapineuzumab for mild to moderate Alzheimer's disease in two global, randomized, phase 3 trials

…, BT Wyman, L Hua, L Yang, HR Brashear… - Alzheimer's research & …, 2016 - Springer
Background Our objective was to evaluate the efficacy (clinical and biomarker) and safety of
intravenous bapineuzumab in patients with mild to moderate Alzheimer’s disease (AD). …