Inflammation clearly occurs in pathologically vulnerable regions of the Alzheimer’s disease (AD)
brain, and it does so with the full complexity of local peripheral inflammatory responses. …

Clinicopathologic correlation studies are critically important for the field of Alzheimer disease
(AD) research. Studies on human subjects with autopsy confirmation entail numerous …

… in Sampathu’s scheme; Mackenzie’s type 2 maps to Sampathu’s type 1 and Mackenzie’s
type 3 maps to Sampathu’s type 2. In this review we use the Mackenzie’s classification scheme …

Ubiquitin-positive, tau- and α-synuclein–negative inclusions are hallmarks of frontotemporal
lobar degeneration with ubiquitin-positive inclusions and amyotrophic lateral sclerosis. …

Several families have been reported with autosomal-dominant frontotemporal dementia (FTD)
and amyotrophic lateral sclerosis (ALS), genetically linked to chromosome 9p21. Here, we …

Frontotemporal dementia (FTD) is the second most common cause of dementia in people
under the age of 65 years 1 . A large proportion of FTD patients (35–50%) have a family history …

We recommend a new term, “primary age-related tauopathy” (PART), to describe a pathology
that is commonly observed in the brains of aged individuals. Many autopsy studies have …

… FTLD-U is characterized by ubiquitin-immunoreactive (ub-ir) … In addition, familial FTLD-U
patients frequently have ub-ir ‘cat… These families all presented with ub-ir NCI and additionally …

Microglia maintain homeostasis in the brain, but whether aberrant microglial activation can
cause neurodegeneration remains controversial. Here, we use transcriptome profiling to …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related
neurodegenerative disorders with shared genetic etiologies and overlapping clinical and …