The role of the gut–brain axis in alcohol use disorders

J Gorky, J Schwaber - Progress in Neuro-Psychopharmacology and …, 2016 - Elsevier
Neuroimmune and inflammatory processes have been locally associated with the amygdala
in alcohol exposure and withdrawal. We and others have suggested that this inflammation …

[HTML][HTML] Single-cell glia and neuron gene expression in the central amygdala in opioid withdrawal suggests inflammation with correlated gut dysbiosis

…, J Park, A Srivastava, BAS Reyes, J Gorky… - Frontiers in …, 2019 - frontiersin.org
Drug-seeking in opioid dependence is due in part to the severe negative emotion associated
with the withdrawal syndrome. It is well-established that negative emotional states emerge …

[PDF][PDF] A comprehensive integrated anatomical and molecular atlas of rat intrinsic cardiac nervous system

S Achanta, J Gorky, C Leung, A Moss, S Robbins… - Iscience, 2020 - cell.com
We have developed and integrated several technologies including whole-organ imaging
and software development to support an initial precise 3D neuroanatomical mapping and …

The impact of lesion in-painting and registration methods on voxel-based morphometry in detecting regional cerebral gray matter atrophy in multiple sclerosis

…, S Tauhid, A Arora, J Gorky… - American Journal …, 2012 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: VBM has been widely used to study GM atrophy in MS.
MS lesions lead to segmentation and registration errors that may affect the reliability of VBM …

[HTML][HTML] Investigating the effects of brainstem neuronal adaptation on cardiovascular homeostasis

JH Park, J Gorky, B Ogunnaike, R Vadigepalli… - Frontiers in …, 2020 - frontiersin.org
… f min,j and f max,j represent the firing frequency output range of the jth neuronal subtype or
neuronal population. The variable f input,j … is represented by f midpt,j and reflects the range of …

[HTML][HTML] GutLogo: Agent-based modeling framework to investigate spatial and temporal dynamics in the gut microbiome

C Lin, J Culver, B Weston, E Underhill, J Gorky… - PLoS …, 2018 - journals.plos.org
Knowledge of the spatial and temporal dynamics of the gut microbiome is essential to
understanding the state of human health, as over a hundred diseases have been correlated with …

[HTML][HTML] An agent-based model to investigate microbial initiation of Alzheimer's via the olfactory system

…, C Battistoni, R McNulty, F Morales, J Gorky… - Theoretical Biology and …, 2020 - Springer
Background Alzheimer’s disease (AD) is a degenerative brain disease. A novel agent-based
modelling framework was developed in NetLogo 3D to provide fundamental insights into …

[HTML][HTML] Conceptualization of a parasympathetic endocrine system

J Gorky, J Schwaber - Frontiers in neuroscience, 2019 - frontiersin.org
We here propose a parasympathetic endocrine system (PES) comprised of circulating peptides
released from secretory cells in the gut, significantly modulated by vagal projections from …

A Physiologically‐Based Pharmacokinetic Model for Targeting Calcitriol‐Conjugated Quantum Dots to Inflammatory Breast Cancer Cells

…, M Wagner, RJ Schaefer, J Gorky… - Clinical and …, 2019 - Wiley Online Library
Quantum dots ( QD s) conjugated with 1,25 dihydroxyvitamin D3 (calcitriol) and Mucin‐1 (
MUC ‐1) antibodies ( SM 3) have been found to target inflammatory breast cancer ( IBC ) …

[PDF][PDF] Input-output signal processing plasticity of vagal motor neurons in response to cardiac ischemic injury

J Gorky, A Moss, M Balycheva, R Vadigepalli… - Iscience, 2021 - cell.com
Vagal stimulation is emerging as the next frontier in bioelectronic medicine to modulate
peripheral organ health and treat disease. The neuronal molecular phenotypes in the dorsal …