Induction of neuronal death by ER stress in Alzheimer's disease

T Katayama, K Imaizumi, T Manabe, J Hitomi… - Journal of chemical …, 2004 - Elsevier
Recent studies have suggested that neuronal death in Alzheimer’s disease (AD) or ischemia
could arise from dysfunction of the endoplasmic reticulum (ER). Inhibition of protein …

[HTML][HTML] Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway

J Hitomi, DE Christofferson, A Ng, J Yao, A Degterev… - Cell, 2008 - cell.com
Stimulation of death receptors by agonists such as FasL and TNFα activates apoptotic cell
death in apoptotic-competent conditions or a type of necrotic cell death dependent on RIP1 …

Identification of RIP1 kinase as a specific cellular target of necrostatins

A Degterev, J Hitomi, M Germscheid, IL Ch'en… - Nature chemical …, 2008 - nature.com
Necroptosis is a cellular mechanism of necrotic cell death induced by apoptotic stimuli in
the form of death domain receptor engagement by their respective ligands under conditions …

Cohort profile: Tohoku medical megabank project birth and three-generation cohort study (TMM BirThree cohort study): rationale, progress and perspective

…, K Tanno, K Sakata, A Shimizu, J Hitomi… - International journal …, 2020 - academic.oup.com
Although a large sample size is useful for the elucidation of what is called ‘missing heritability’,
which is an unexplained part of a total phenotypic variance in a quantitative trait or …

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death

J Hitomi, T Katayama, Y Eguchi, T Kudo… - The Journal of cell …, 2004 - rupress.org
Recent studies have suggested that neuronal death in Alzheimer's disease or ischemia could
arise from dysfunction of the endoplasmic reticulum (ER). Although caspase-12 has been …

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

…, K Imaizumi, N Sato, K Miyoshi, T Kudo, J Hitomi… - Nature cell …, 1999 - nature.com
Missense mutations in the human presenilin-1 (PS1) gene, which is found on chromosome
14, cause early-onset familial Alzheimer’s disease (FAD). FAD-linked PS1 variants alter …

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

…, Y Li, J Hitomi, H Zhu, H Chen, L Mayo, J Geng… - Science, 2016 - science.org
Mutations in the optineurin (OPTN) gene have been implicated in both familial and sporadic
amyotrophic lateral sclerosis (ALS). However, the role of this protein in the central nervous …

Live imaging of lymphatic development in the zebrafish

K Yaniv, S Isogai, D Castranova, L Dye, J Hitomi… - Nature medicine, 2006 - nature.com
The lymphatic system has become the subject of great interest in recent years because of its
important role in normal and pathological processes. Progress in understanding the origins …

Bcl11b is required for differentiation and survival of αβ T lymphocytes

…, J Inoue, N Takeda, J Sakata, Y Mishima, J Hitomi… - Nature …, 2003 - nature.com
… semi-quantitative information on the extent of individual D β to J β and V β to D β
rearrangements (Fig. 3c). The D β to J β rearrangements occurred normally, whereas the V β to D β …

Apoptosis induced by endoplasmic reticulum stress depends on activation of caspase-3 via caspase-12

J Hitomi, T Katayama, M Taniguchi, A Honda… - Neuroscience …, 2004 - Elsevier
Recently, endoplasmic reticulum (ER) dysfunction has been implicated in neuronal death in
patients with Alzheimer's disease. Treatment of human neuroblastoma cells with ER stress …