Induction of neuronal death by ER stress in Alzheimer's disease
T Katayama, K Imaizumi, T Manabe, J Hitomi… - Journal of chemical …, 2004 - Elsevier
Recent studies have suggested that neuronal death in Alzheimer’s disease (AD) or ischemia
could arise from dysfunction of the endoplasmic reticulum (ER). Inhibition of protein …
could arise from dysfunction of the endoplasmic reticulum (ER). Inhibition of protein …
[HTML][HTML] Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway
J Hitomi, DE Christofferson, A Ng, J Yao, A Degterev… - Cell, 2008 - cell.com
Stimulation of death receptors by agonists such as FasL and TNFα activates apoptotic cell
death in apoptotic-competent conditions or a type of necrotic cell death dependent on RIP1 …
death in apoptotic-competent conditions or a type of necrotic cell death dependent on RIP1 …
Identification of RIP1 kinase as a specific cellular target of necrostatins
A Degterev, J Hitomi, M Germscheid, IL Ch'en… - Nature chemical …, 2008 - nature.com
Necroptosis is a cellular mechanism of necrotic cell death induced by apoptotic stimuli in
the form of death domain receptor engagement by their respective ligands under conditions …
the form of death domain receptor engagement by their respective ligands under conditions …
Cohort profile: Tohoku medical megabank project birth and three-generation cohort study (TMM BirThree cohort study): rationale, progress and perspective
…, K Tanno, K Sakata, A Shimizu, J Hitomi… - International journal …, 2020 - academic.oup.com
Although a large sample size is useful for the elucidation of what is called ‘missing heritability’,
which is an unexplained part of a total phenotypic variance in a quantitative trait or …
which is an unexplained part of a total phenotypic variance in a quantitative trait or …
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death
J Hitomi, T Katayama, Y Eguchi, T Kudo… - The Journal of cell …, 2004 - rupress.org
Recent studies have suggested that neuronal death in Alzheimer's disease or ischemia could
arise from dysfunction of the endoplasmic reticulum (ER). Although caspase-12 has been …
arise from dysfunction of the endoplasmic reticulum (ER). Although caspase-12 has been …
Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response
…, K Imaizumi, N Sato, K Miyoshi, T Kudo, J Hitomi… - Nature cell …, 1999 - nature.com
Missense mutations in the human presenilin-1 (PS1) gene, which is found on chromosome
14, cause early-onset familial Alzheimer’s disease (FAD). FAD-linked PS1 variants alter …
14, cause early-onset familial Alzheimer’s disease (FAD). FAD-linked PS1 variants alter …
RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS
Mutations in the optineurin (OPTN) gene have been implicated in both familial and sporadic
amyotrophic lateral sclerosis (ALS). However, the role of this protein in the central nervous …
amyotrophic lateral sclerosis (ALS). However, the role of this protein in the central nervous …
Live imaging of lymphatic development in the zebrafish
K Yaniv, S Isogai, D Castranova, L Dye, J Hitomi… - Nature medicine, 2006 - nature.com
The lymphatic system has become the subject of great interest in recent years because of its
important role in normal and pathological processes. Progress in understanding the origins …
important role in normal and pathological processes. Progress in understanding the origins …
Bcl11b is required for differentiation and survival of αβ T lymphocytes
…, J Inoue, N Takeda, J Sakata, Y Mishima, J Hitomi… - Nature …, 2003 - nature.com
… semi-quantitative information on the extent of individual D β to J β and V β to D β
rearrangements (Fig. 3c). The D β to J β rearrangements occurred normally, whereas the V β to D β …
rearrangements (Fig. 3c). The D β to J β rearrangements occurred normally, whereas the V β to D β …
Apoptosis induced by endoplasmic reticulum stress depends on activation of caspase-3 via caspase-12
J Hitomi, T Katayama, M Taniguchi, A Honda… - Neuroscience …, 2004 - Elsevier
Recently, endoplasmic reticulum (ER) dysfunction has been implicated in neuronal death in
patients with Alzheimer's disease. Treatment of human neuroblastoma cells with ER stress …
patients with Alzheimer's disease. Treatment of human neuroblastoma cells with ER stress …