… We thank Yair Argon, Keri Sanborn, and members of the Burkhardt laboratory for critical
reading of the manuscript. This work was supported by NIH grants R01-AI065644 and R01-…

… The authors thank members of the Burkhardt lab for helpful conversations, and Drs.
Nathan … Babich A, Li S, O’Connor RS, Milone MC, Freedman BD, Burkhardt JK. F-actin …

BACKGROUND: This prospective, single-center study assesses progression-free survival (PFS)
and overall survival (OS) in patients with recurrent glioblastoma multiforme (GBM) …

… ), dynactin disruption results in the accumulation of Golgi proteins at the same sites with
intermediate compartment markers and newly synthesized proteins exiting the ER (Burkhardt, JK…

Binding of either ligand or agonistic antibodies to the death receptor CD95 (APO-1/Fas) induces
the formation of the death-inducing signaling complex (DISC). We now show that signal …

Background The engagement of the T cell receptor results in actin cytoskeletal reorganization
at the immune synapse (IS) and the triggering of biochemical signaling cascades leading …

While CD19-directed chimeric antigen receptor (CAR) T cells can induce remission in
patients with B cell acute lymphoblastic leukemia (ALL), a large subset relapse with CD19 − …

… Burkhardt, Susan Hester, Michael Hortsch,* David I. Meyer,* and Yair Argon … DL Wiest and
JK Burkhardt were supported by NIH training grants and Y. Argon was supported by a junior …

Microtubules facilitate the maturation of phagosomes by favoring their interactions with
endocytic compartments. Here, we show that phagosomes move within cells along tracks of …

The large mucin CD43 is actively excluded from T cell/APC interaction sites, concentrating in
a membrane domain distal to the site of TCR engagement. The cytoplasmic region of CD43 …