User profiles for J. Lah

James Lah

Department of Neurology, Emory University
Verified email at emory.edu
Cited by 30328

Toxin–antitoxin modules as bacterial metabolic stress managers

L Buts, J Lah, MH Dao-Thi, L Wyns, R Loris - Trends in biochemical …, 2005 - cell.com
Bacterial genomes frequently contain operons that encode a toxin and its antidote. These ‘toxin–antitoxin
(TA) modules' have an important role in bacterial stress physiology and might …

Mild cognitive impairment: an opportunity to identify patients at high risk for progression to Alzheimer's disease

A Levey, J Lah, F Goldstein, K Steenland, D Bliwise - Clinical therapeutics, 2006 - Elsevier
BACKGROUND:: There is increasing evidence that subtle losses in cognitive function may
be symptomatic of a transition to early Alzheimer's disease (AD). Ongoing research is …

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

…, JA Kaye, R Kim, EH Koo, NW Kowall, JJ Lah… - Nature …, 2011 - nature.com
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …

[HTML][HTML] Variant of TREM2 Associated with the Risk of Alzheimer's Disease

…, J Huttenlocher, AI Levey, JJ Lah… - … England Journal of …, 2013 - Mass Medical Soc
Background Sequence variants, including the ε4 allele of apolipoprotein E, have been
associated with the risk of the common late-onset form of Alzheimer's disease. Few rare variants …

Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and …

…, S Rangaraju, I Hajjar, JM Shulman, JJ Lah… - Nature medicine, 2020 - nature.com
Our understanding of Alzheimer’s disease (AD) pathophysiology remains incomplete. Here
we used quantitative mass spectrometry and coexpression network analysis to conduct the …

A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease

…, D Hannequin, D Wallon, SB Berman, JJ Lah… - Nature medicine, 2021 - nature.com
Dominantly inherited Alzheimer’s disease (DIAD) causes predictable biological changes
decades before the onset of clinical symptoms, enabling testing of interventions in the …

[HTML][HTML] Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level

…, M Gearing, TS Wingo, AP Wingo, JJ Lah… - Nature …, 2022 - nature.com
The biological processes that are disrupted in the Alzheimer’s disease (AD) brain remain
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

…, AC McKee, M Gearing, AI Levey, JJ Lah, J Hardy… - Nature …, 2010 - nature.com
Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile
dementia. The predominant neuropathology is FTLD with TAR DNA-binding protein (TDP-43) …

Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes

…, R Kim, EH Koo, NW Kowall, JJ Lah… - Archives of …, 2010 - jamanetwork.com
Objectives: To determine whether genotypes at CLU, PICALM, and CR1 confer risk for
Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced by …

[HTML][HTML] Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease

…, T Ikeuchi, H Mori, J Levin, M Farlow, JJ Lah… - Nature medicine, 2023 - nature.com
Alzheimer’s disease (AD) pathology develops many years before the onset of cognitive
symptoms. Two pathological processes—aggregation of the amyloid-β (Aβ) peptide into plaques …