User profiles for J. Lah
James LahDepartment of Neurology, Emory University Verified email at emory.edu Cited by 30328 |
Toxin–antitoxin modules as bacterial metabolic stress managers
L Buts, J Lah, MH Dao-Thi, L Wyns, R Loris - Trends in biochemical …, 2005 - cell.com
Bacterial genomes frequently contain operons that encode a toxin and its antidote. These ‘toxin–antitoxin
(TA) modules' have an important role in bacterial stress physiology and might …
(TA) modules' have an important role in bacterial stress physiology and might …
Mild cognitive impairment: an opportunity to identify patients at high risk for progression to Alzheimer's disease
BACKGROUND:: There is increasing evidence that subtle losses in cognitive function may
be symptomatic of a transition to early Alzheimer's disease (AD). Ongoing research is …
be symptomatic of a transition to early Alzheimer's disease (AD). Ongoing research is …
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …
[HTML][HTML] Variant of TREM2 Associated with the Risk of Alzheimer's Disease
Background Sequence variants, including the ε4 allele of apolipoprotein E, have been
associated with the risk of the common late-onset form of Alzheimer's disease. Few rare variants …
associated with the risk of the common late-onset form of Alzheimer's disease. Few rare variants …
Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and …
Our understanding of Alzheimer’s disease (AD) pathophysiology remains incomplete. Here
we used quantitative mass spectrometry and coexpression network analysis to conduct the …
we used quantitative mass spectrometry and coexpression network analysis to conduct the …
A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease
Dominantly inherited Alzheimer’s disease (DIAD) causes predictable biological changes
decades before the onset of clinical symptoms, enabling testing of interventions in the …
decades before the onset of clinical symptoms, enabling testing of interventions in the …
[HTML][HTML] Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level
The biological processes that are disrupted in the Alzheimer’s disease (AD) brain remain
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions
Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile
dementia. The predominant neuropathology is FTLD with TAR DNA-binding protein (TDP-43) …
dementia. The predominant neuropathology is FTLD with TAR DNA-binding protein (TDP-43) …
Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes
Objectives: To determine whether genotypes at CLU, PICALM, and CR1 confer risk for
Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced by …
Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced by …
[HTML][HTML] Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease
Alzheimer’s disease (AD) pathology develops many years before the onset of cognitive
symptoms. Two pathological processes—aggregation of the amyloid-β (Aβ) peptide into plaques …
symptoms. Two pathological processes—aggregation of the amyloid-β (Aβ) peptide into plaques …