User profiles for J. Nazarian

Javad Nazarian

Associate Professor, Integrative Systems Biology, George Washington University, Head …
Verified email at CNMC.org
Cited by 5482

Advances in the proteomic investigation of the cell secretome

…, S Duguez, E An, D Pillai, J Nazarian… - Expert review of …, 2012 - Taylor & Francis
Studies of the cell secretome have greatly increased in recent years owing to improvements
in proteomic platforms, mass spectrometry instrumentation and to the increased interaction …

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

…, KR Taylor, A Mackay, AE Bendel, J Nazarian… - Nature …, 2014 - nature.com
Diffuse intrinsic pontine glioma (DIPG) is a fatal brain cancer that arises in the brainstem of
children, with no effective treatment and near 100% fatality. The failure of most therapies can …

Functionally defined therapeutic targets in diffuse intrinsic pontine glioma

…, MN Svalina, N Wang, C Hawkins, J Nazarian… - Nature medicine, 2015 - nature.com
Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. We performed a chemical
screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated …

[PDF][PDF] The pediatric cell atlas: defining the growth phase of human development at single-cell resolution

…, AB Muir, LX Garmire, SB Snapper, J Nazarian… - Developmental cell, 2019 - cell.com
Single-cell gene expression analyses of mammalian tissues have uncovered profound
stage-specific molecular regulatory phenomena that have changed the understanding of unique …

[PDF][PDF] Integrated proteogenomic characterization across major histological types of pediatric brain cancer

…, N Young, S Leary, J Moon, VA Petyuk, J Nazarian… - Cell, 2020 - cell.com
We report a comprehensive proteogenomics analysis, including whole-genome sequencing,
RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 …

[HTML][HTML] Clinical, radiologic, pathologic, and molecular characteristics of long-term survivors of diffuse intrinsic pontine glioma (DIPG): a collaborative report from the …

…, M Benesch, R Drissi, J Nazarian… - Journal of clinical …, 2018 - ncbi.nlm.nih.gov
Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with a median
survival of< 1 year. The International and European Society for Pediatric Oncology DIPG …

Mechanisms of imipridones in targeting mitochondrial metabolism in cancer cells

…, SM Waszak, MA Grotzer, S Mueller, J Nazarian - Neuro …, 2021 - academic.oup.com
ONC201 is the first member of the imipridone family of anticancer drugs to enter the clinic
for the treatment of diverse solid and hematologic cancers. A subset of pediatric and adult …

[HTML][HTML] Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma

…, RJ Packer, N Jabado, J Majewski, J Nazarian - Nature …, 2016 - nature.com
Diffuse Intrinsic Pontine Gliomas (DIPGs) are deadly paediatric brain tumours where needle
biopsies help guide diagnosis and targeted therapies. To address spatial heterogeneity, …

Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma

…, D Hambardzumyan, TR Walker, K Helmy, J Nazarian… - Cancer research, 2010 - AACR
Brainstem gliomas (BSG) are a rare group of central nervous system tumors that arise mostly
in children and usually portend a particularly poor prognosis. We report the development of …

[HTML][HTML] Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways

…, J Grill, C Kline, S Mueller, A Resnick, J Nazarian… - Cancer discovery, 2023 - AACR
The clinical, radiographic, and molecular analyses included in this study demonstrate the
efficacy of ONC201 in H3K27M-mutant DMG and support ONC201 as the first monotherapy to …