User profiles for J. Nazarian
Javad NazarianAssociate Professor, Integrative Systems Biology, George Washington University, Head … Verified email at CNMC.org Cited by 5482 |
Advances in the proteomic investigation of the cell secretome
…, S Duguez, E An, D Pillai, J Nazarian… - Expert review of …, 2012 - Taylor & Francis
Studies of the cell secretome have greatly increased in recent years owing to improvements
in proteomic platforms, mass spectrometry instrumentation and to the increased interaction …
in proteomic platforms, mass spectrometry instrumentation and to the increased interaction …
Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations
Diffuse intrinsic pontine glioma (DIPG) is a fatal brain cancer that arises in the brainstem of
children, with no effective treatment and near 100% fatality. The failure of most therapies can …
children, with no effective treatment and near 100% fatality. The failure of most therapies can …
Functionally defined therapeutic targets in diffuse intrinsic pontine glioma
Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood cancer. We performed a chemical
screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated …
screen in patient-derived DIPG cultures along with RNA-seq analyses and integrated …
[PDF][PDF] The pediatric cell atlas: defining the growth phase of human development at single-cell resolution
Single-cell gene expression analyses of mammalian tissues have uncovered profound
stage-specific molecular regulatory phenomena that have changed the understanding of unique …
stage-specific molecular regulatory phenomena that have changed the understanding of unique …
[PDF][PDF] Integrated proteogenomic characterization across major histological types of pediatric brain cancer
We report a comprehensive proteogenomics analysis, including whole-genome sequencing,
RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 …
RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 …
[HTML][HTML] Clinical, radiologic, pathologic, and molecular characteristics of long-term survivors of diffuse intrinsic pontine glioma (DIPG): a collaborative report from the …
…, M Benesch, R Drissi, J Nazarian… - Journal of clinical …, 2018 - ncbi.nlm.nih.gov
Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with a median
survival of< 1 year. The International and European Society for Pediatric Oncology DIPG …
survival of< 1 year. The International and European Society for Pediatric Oncology DIPG …
Mechanisms of imipridones in targeting mitochondrial metabolism in cancer cells
ONC201 is the first member of the imipridone family of anticancer drugs to enter the clinic
for the treatment of diverse solid and hematologic cancers. A subset of pediatric and adult …
for the treatment of diverse solid and hematologic cancers. A subset of pediatric and adult …
[HTML][HTML] Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma
Diffuse Intrinsic Pontine Gliomas (DIPGs) are deadly paediatric brain tumours where needle
biopsies help guide diagnosis and targeted therapies. To address spatial heterogeneity, …
biopsies help guide diagnosis and targeted therapies. To address spatial heterogeneity, …
Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma
…, D Hambardzumyan, TR Walker, K Helmy, J Nazarian… - Cancer research, 2010 - AACR
Brainstem gliomas (BSG) are a rare group of central nervous system tumors that arise mostly
in children and usually portend a particularly poor prognosis. We report the development of …
in children and usually portend a particularly poor prognosis. We report the development of …
[HTML][HTML] Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways
The clinical, radiographic, and molecular analyses included in this study demonstrate the
efficacy of ONC201 in H3K27M-mutant DMG and support ONC201 as the first monotherapy to …
efficacy of ONC201 in H3K27M-mutant DMG and support ONC201 as the first monotherapy to …