Correlates of physical activity: why are some people physically active and others not?
Physical inactivity is an important contributor to non-communicable diseases in countries of
high income, and increasingly so in those of low and middle income. Understanding why …
high income, and increasingly so in those of low and middle income. Understanding why …
[HTML][HTML] Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
…, R Bannister, HC Hui, N Larson, R Strickley, J Wells… - Nature, 2016 - nature.com
… four wells of infected untreated cells and four wells of … replaced with 100 μl per well of media
containing the appropriate … Vero cell monolayers in 96-well plates to determine the tissue …
containing the appropriate … Vero cell monolayers in 96-well plates to determine the tissue …
[HTML][HTML] Intestinal permeability–a new target for disease prevention and therapy
… The barrier assessments are further hindered by the natural variability of this functional entity
depending on species and genes as well as on diet and other environmental factors. In the …
depending on species and genes as well as on diet and other environmental factors. In the …
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
JA Wells, CL McClendon - Nature, 2007 - nature.com
… These small molecules do not bind well to other anti-apoptotic members of the Bcl-2 family
such as MCL1 (myeloid cell leukaemia sequence 1) and Bcl-B 46 . The most potent of these, …
such as MCL1 (myeloid cell leukaemia sequence 1) and Bcl-B 46 . The most potent of these, …
[HTML][HTML] Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430
TK Warren, J Wells, RG Panchal, KS Stuthman… - Nature, 2014 - nature.com
Filoviruses are emerging pathogens and causative agents of viral haemorrhagic fever. Case
fatality rates of filovirus disease outbreaks are among the highest reported for any human …
fatality rates of filovirus disease outbreaks are among the highest reported for any human …
[HTML][HTML] A systematic screen of FDA-approved drugs for inhibitors of biological threat agents
…, S Bavari, RG Panchal, TK Warren, JB Wells… - PloS one, 2013 - journals.plos.org
… goal, since currently approved drugs already have well-established safety and pharmacokinetic
profiles in patients, as well as manufacturing and distribution networks. Therefore, …
profiles in patients, as well as manufacturing and distribution networks. Therefore, …
Advanced antisense therapies for postexposure protection against lethal filovirus infections
TK Warren, KL Warfield, J Wells, DL Swenson… - Nature medicine, 2010 - nature.com
Currently, no vaccines or therapeutics are licensed to counter Ebola or Marburg viruses, highly
pathogenic filoviruses that are causative agents of viral hemorrhagic fever. Here we show …
pathogenic filoviruses that are causative agents of viral hemorrhagic fever. Here we show …
Antiviral activity of hop constituents against a series of DNA and RNA viruses
…, J Wells, L Chuvala, S Sloane, R Paulman, J Russell… - Antiviral research, 2004 - Elsevier
We investigated whether crude hop extracts and purified hop components representing every
major chemical class of hop compound have antiviral activity. These hop constituents were …
major chemical class of hop compound have antiviral activity. These hop constituents were …
Cross-national epidemiology of major depression and bipolar disorder
…, JP Lepine, SC Newman, M Rubio-Stipec, JE Wells… - Jama, 1996 - jamanetwork.com
Objective. —To estimate the rates and patterns of major depression and bipolar disorder
based on cross-national epidemiologic surveys. Design and Setting. —Population-based …
based on cross-national epidemiologic surveys. Design and Setting. —Population-based …
Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative
Context There is limited information on the prevalence and correlates of bipolar spectrum
disorder in international population-based studies using common methods. Objectives To …
disorder in international population-based studies using common methods. Objectives To …