Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

…, RH Duerr, DP McGovern, KY Hui, JC Lee… - Nature, 2012 - nature.com
Crohn’s disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …

An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19

…, BL Hurst, EP Kadar, AS Kalgutkar, JC Lee, J Lee… - Science, 2021 - science.org
The worldwide outbreak of COVID-19 caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has become a global pandemic. Alongside vaccines, antiviral …

Measurements of Ω and Λ from 42 high-redshift supernovae

…, IM Hook, AG Kim, MY Kim, JC Lee… - The Astrophysical …, 1999 - iopscience.iop.org
We report measurements of the mass density, Ω $\mathstrut {_ {M}} $, and cosmological-constant
energy density, Ω $\mathstrut {_ {{\Lambda}}} $, of the universe based on the analysis …

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

JG Paez, PA Janne, JC Lee, S Tracy, H Greulich… - Science, 2004 - science.org
Receptor tyrosine kinase genes were sequenced in non–small cell lung cancer (NSCLC)
and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene …

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

JC Lee, JT Laydon, PC McDonnell, TF Gallagher… - Nature, 1994 - nature.com
Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is
inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio-…

[PDF][PDF] Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

…, JJ Clark, S Moore, J Adelsperger, S Koo, JC Lee… - Cancer cell, 2005 - cell.com
Polycythemia vera (PV), essential thrombocythemia (ET), and myeloid metaplasia with
myelofibrosis (MMM) are clonal disorders arising from hematopoietic progenitors. An internet-…

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

…, SC Ng, R Alberts, A Takahashi, S Ripke, JC Lee… - Nature …, 2015 - nature.com
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

…, CW Lees, A Franke, M D'Amato, KD Taylor, JC Lee… - Nature …, 2011 - nature.com
Genome-wide association studies and candidate gene studies in ulcerative colitis have
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-…

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

…, R Meier, P Cohen, TF Gallagher, PR Young, JC Lee - FEBS letters, 1995 - Elsevier
A class of pyridinyl imidazoles inhibit the MAP kinase homologue, termed here reactivating
kinase (RK) [Lee et al. (1994) Nature 372, 739–746]. We now show that one of these …

[HTML][HTML] Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors

…, PN Rao, R Beroukhim, TC Peck, JC Lee… - … England Journal of …, 2005 - Mass Medical Soc
Background The epidermal growth factor receptor (EGFR) is frequently amplified, overexpressed,
or mutated in glioblastomas, but only 10 to 20 percent of patients have a response to …