Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Crohn’s disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19
…, BL Hurst, EP Kadar, AS Kalgutkar, JC Lee, J Lee… - Science, 2021 - science.org
The worldwide outbreak of COVID-19 caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has become a global pandemic. Alongside vaccines, antiviral …
coronavirus 2 (SARS-CoV-2) has become a global pandemic. Alongside vaccines, antiviral …
Measurements of Ω and Λ from 42 high-redshift supernovae
…, IM Hook, AG Kim, MY Kim, JC Lee… - The Astrophysical …, 1999 - iopscience.iop.org
We report measurements of the mass density, Ω $\mathstrut {_ {M}} $, and cosmological-constant
energy density, Ω $\mathstrut {_ {{\Lambda}}} $, of the universe based on the analysis …
energy density, Ω $\mathstrut {_ {{\Lambda}}} $, of the universe based on the analysis …
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
JG Paez, PA Janne, JC Lee, S Tracy, H Greulich… - Science, 2004 - science.org
Receptor tyrosine kinase genes were sequenced in non–small cell lung cancer (NSCLC)
and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene …
and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene …
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
JC Lee, JT Laydon, PC McDonnell, TF Gallagher… - Nature, 1994 - nature.com
Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is
inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio-…
inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio-…
[PDF][PDF] Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
…, JJ Clark, S Moore, J Adelsperger, S Koo, JC Lee… - Cancer cell, 2005 - cell.com
Polycythemia vera (PV), essential thrombocythemia (ET), and myeloid metaplasia with
myelofibrosis (MMM) are clonal disorders arising from hematopoietic progenitors. An internet-…
myelofibrosis (MMM) are clonal disorders arising from hematopoietic progenitors. An internet-…
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Genome-wide association studies and candidate gene studies in ulcerative colitis have
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-…
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-…
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
…, R Meier, P Cohen, TF Gallagher, PR Young, JC Lee - FEBS letters, 1995 - Elsevier
A class of pyridinyl imidazoles inhibit the MAP kinase homologue, termed here reactivating
kinase (RK) [Lee et al. (1994) Nature 372, 739–746]. We now show that one of these …
kinase (RK) [Lee et al. (1994) Nature 372, 739–746]. We now show that one of these …
[HTML][HTML] Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
…, PN Rao, R Beroukhim, TC Peck, JC Lee… - … England Journal of …, 2005 - Mass Medical Soc
Background The epidermal growth factor receptor (EGFR) is frequently amplified, overexpressed,
or mutated in glioblastomas, but only 10 to 20 percent of patients have a response to …
or mutated in glioblastomas, but only 10 to 20 percent of patients have a response to …