Poststroke cognitive impairment and dementia (PSCID) is a major source of morbidity and
mortality after stroke worldwide. PSCID occurs as a consequence of ischemic stroke, …

The era of precision medicine has arrived and conveys tremendous potential, particularly
for stroke neurology. The diagnosis of stroke, its underlying aetiology, theranostic strategies, …

Stroke is a devastating neurological disease with limited functional recovery. Stroke affects
all cellular elements of the brain and impacts areas traditionally classified as both gray matter …

We have previously shown that myelin abnormalities characterize the normal aging process
of the brain and that an age-associated reduction in Klotho is conserved across species. …

Background and Purpose— Recovery from stroke requires neuroplasticity within surviving
adjacent cortex. The axon initial segment (AIS) is the site of action potential initiation and a …

White matter stroke is a distinct stroke subtype, accounting for up to 25% of stroke and
constituting the second leading cause of dementia. The biology of possible tissue repair after …

Myelin provides important insulating properties to axons allowing for propagation of action
potentials over large distances at high velocity. Disruption of the myelin sheath could …

Background and Purpose: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
infection is associated with an increased rate of cerebrovascular events including ischemic …

The concept of vascular contributions to cognitive impairment and dementia (VCID) derives
from more than two decades of research indicating that (1) most older individuals with …

Cerebral microvascular disease predominantly affects brain white matter and deep grey
matter, resulting in ischaemic damage that ranges from lacunar infarcts to white matter …